Literature DB >> 9045945

Tumor necrosis factor production and colon cancer.

H Ito1, A Yagita, M Fujitsuka, Y Atomi, I Tatekawa.   

Abstract

Tumor necrosis factor (TNF) production in B10 mice exhibiting H-2 gene heterogeneity and in C3H/He mice differing in lipopolysaccharide (LPS) responsiveness was investigated following stimulation with OK-432. TNF-producing capacity in these mice was H-2-restricted, while their LPS responsiveness was independent of the gene. TNF production in humans was found to be HLA-B antigen-restricted. An investigation was then made of the effect of endogenous TNF induction with OK-432 on the survival rate of colorectal cancer patients. Patients in the TNF-producing group showed a trend toward having a better prognosis as compared to those in the TNF-nonproducing group. Cancer therapy formulated with consideration of host responsiveness to OK-432 may afford greater therapeutic benefit and may prolong survival.

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Year:  1996        PMID： 9045945      PMCID： PMC5921006          DOI： 10.1111/j.1349-7006.1996.tb03126.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  10 in total

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Authors:  U Müller; C V Jongeneel; S A Nedospasov; K F Lindahl; M Steinmetz
Journal:  Nature       Date:  1987 Jan 15-21       Impact factor: 49.962

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Authors: 
Journal:  Immunobiology       Date:  1987-08       Impact factor: 3.144

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Journal:  Acta Med Scand       Date:  1986

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Authors:  E A Carswell; L J Old; R L Kassel; S Green; N Fiore; B Williamson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

7.  Linkage of TNF genes to the HLA-B locus.

Authors:  H Inoko; J Trowsdale
Journal:  Nucleic Acids Res       Date:  1987-11-11       Impact factor: 16.971

8.  Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin.

Authors:  M A Freudenberg; D Keppler; C Galanos
Journal:  Infect Immun       Date:  1986-03       Impact factor: 3.441

9.  Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma.

Authors:  C G Moertel; T R Fleming; J S Macdonald; D G Haller; J A Laurie; P J Goodman; J S Ungerleider; W A Emerson; D C Tormey; J H Glick
Journal:  N Engl J Med       Date:  1990-02-08       Impact factor: 91.245

10.  Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

Authors:  G Messer; U Spengler; M C Jung; G Honold; K Blömer; G R Pape; G Riethmüller; E H Weiss
Journal:  J Exp Med       Date:  1991-01-01       Impact factor: 14.307
  10 in total
  1 in total

1.  Mouse colitis induced by Escherichia coli producing Yersinia enterocolitica 60-kilodalton heat-shock protein: light and electron microscope study.

Authors:  A Yagita; Y Sukegawa; S Maruyama; N Sato; Y Atomi; H Yamaguchi; S Kamiya; T Ihara; M Sugamata
Journal:  Dig Dis Sci       Date:  1999-02       Impact factor: 3.199
  1 in total

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