Literature DB >> 9045940

Promoting effect of unilateral nephrectomy on urinary bladder carcinogenesis in rats.

S Saikawa1, H Kanamaru, B Li, S Matsukawa, K Okada.   

Abstract

The effect of unilateral nephrectomy on the growth of bladder tumors was investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine(BBN) for 6 weeks by means of macroscopical and microscopical examinations. Unilateral nephrectomy 4 weeks after the initiation of BBN administration significantly increased both the number and the volume of visible tumors per rat as compared with the sham-operated group. Histological examination also revealed that the numbers of papillonodular hyperplasia and cancer per basement membrane were significantly increased by unilateral nephrectomy. The results imply a growth-enhancing effect of unilateral nephrectomy on carcinogenesis of the rat bladder.

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Year:  1996        PMID： 9045940      PMCID： PMC5921012          DOI： 10.1111/j.1349-7006.1996.tb03121.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy.

Authors:  M Nagaike; S Hirao; H Tajima; S Noji; S Taniguchi; K Matsumoto; T Nakamura
Journal:  J Biol Chem       Date:  1991-12-05       Impact factor: 5.157

2.  Further studies on the characterization of a renotropic activity detected in uninephrectomized rat plasma.

Authors:  A García-Ocaña; P Esbrit
Journal:  Exp Nephrol       Date:  1994 Sep-Oct

3.  Transforming growth factor-beta in rat kidney during compensatory renal growth.

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Journal:  Growth Regul       Date:  1993-06

4.  [The role of mechanical stimuli in rat bladder carcinogenesis. Regenerative hyperplasia of rat urinary bladder urothelium after transurethral fulguration].

Authors:  H Akaza; K Koseki; N Moriyama; T Suzuki; T Niijima
Journal:  Nihon Hinyokika Gakkai Zasshi       Date:  1984-10

5.  Cellular proliferation in the urinary tract epithelium of the rat following temporary unilateral renal ischaemia.

Authors:  S Dunn; E M Gibbons; B M Herbertson
Journal:  Br J Exp Pathol       Date:  1976-02

6.  SERUM FACTOR IN RENAL COMPENSATORY HYPERPLASIA.

Authors:  L M LOWENSTEIN; A STERN
Journal:  Science       Date:  1963-12-13       Impact factor: 47.728

7.  DNA synthesis in the urinary tract epithelium of the rat induced by ureteric ligation.

Authors:  B M Herbertson; P R Steele; J Allen
Journal:  Lab Invest       Date:  1981-09       Impact factor: 5.662

8.  Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats.

Authors:  S E Mulroney; A Haramati; H Werner; C Bondy; C T Roberts; D LeRoith
Journal:  Endocrinology       Date:  1992-01       Impact factor: 4.736

9.  Effect of epidermal growth factor in the rat 5/6 renal ablation model.

Authors:  D W Moskowitz; A N Schneider; P H Lane; P G Schmitz; K N Gillespie
Journal:  J Am Soc Nephrol       Date:  1992-11       Impact factor: 10.121

10.  Keratinocyte growth factor causes proliferation of urothelium in vivo.

Authors:  E S Yi; A S Shabaik; D L Lacey; A A Bedoya; S Yin; R M Housley; D M Danilenko; W Benson; A M Cohen; G F Pierce
Journal:  J Urol       Date:  1995-10       Impact factor: 7.450
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