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Literature DB >> 9045937

Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase.

Y Yamashita¹, A Miyazato, K Ohya, U Ikeda, K Shimada, Y Miura, K Ozawa, H Mano.

Abstract

Tec protein-tyrosine kinase (PTK) is the prototype of a new subfamily of non-receptor type PTKs, and is abundantly expressed in hematopoietic tissues. We have revealed that Tec is inducibly tyrosine-phosphorylated and activated by stimulation with a wide range of cytokines. To get more insight into the signaling mechanism through Tec, we have generated a constitutively active form of Tec PTK. Deletion of the Src homology (SH) 3 domain gave rise to a hyperphosphorylated and activated Tec kinase (Tec deltaSH3). The activity of Tec deltaSH3 was confirmed in 293 cells, as well as in cytokine-dependent hematopoietic cells (BA/F3). Tec deltaSH3 should be a useful tool to study the in vivo substrates of Tec PTK.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 1996 PMID： 9045937 PMCID： PMC5921018 DOI： 10.1111/j.1349-7006.1996.tb03118.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

24 in total

1. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.

Authors: H Mano; F Ishikawa; J Nishida; H Hirai; F Takaku
Journal: Oncogene Date: 1990-12 Impact factor: 9.867

2. A tail of two src's: mutatis mutandis.

Authors: T Hunter
Journal: Cell Date: 1987-04-10 Impact factor: 41.582

Review 3. The PH domain: a common piece in the structural patchwork of signalling proteins.

Authors: A Musacchio; T Gibson; P Rice; J Thompson; M Saraste
Journal: Trends Biochem Sci Date: 1993-09 Impact factor: 13.807

4. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

Authors: L Tamagnone; I Lahtinen; T Mustonen; K Virtaneva; F Francis; F Muscatelli; R Alitalo; C I Smith; C Larsson; K Alitalo
Journal: Oncogene Date: 1994-12 Impact factor: 9.867

5. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

Authors: J D Siliciano; T A Morrow; S V Desiderio
Journal: Proc Natl Acad Sci U S A Date: 1992-12-01 Impact factor: 11.205

6. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.

Authors: D Vetrie; I Vorechovský; P Sideras; J Holland; A Davies; F Flinter; L Hammarström; C Kinnon; R Levinsky; M Bobrow
Journal: Nature Date: 1993-01-21 Impact factor: 49.962

7. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.

Authors: R Palacios; M Steinmetz
Journal: Cell Date: 1985-07 Impact factor: 41.582

8. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

Authors: M Machide; H Mano; K Todokoro
Journal: Oncogene Date: 1995-08-17 Impact factor: 9.867

9. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.

Authors: S Tsukada; D C Saffran; D J Rawlings; O Parolini; R C Allen; I Klisak; R S Sparkes; H Kubagawa; T Mohandas; S Quan
Journal: Cell Date: 1993-01-29 Impact factor: 41.582

10. Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines.

Authors: T Matsuda; M Takahashi-Tezuka; T Fukada; Y Okuyama; Y Fujitani; S Tsukada; H Mano; H Hirai; O N Witte; T Hirano
Journal: Blood Date: 1995-02-01 Impact factor: 22.113

5 in total

Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase.

1. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.

2. A tail of two src's: mutatis mutandis.

Review 3. The PH domain: a common piece in the structural patchwork of signalling proteins.

4. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

5. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

6. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.

7. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.

8. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

9. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.

10. Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines.

1. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.

2. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.

3. Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13.

4. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

Review 5. Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease.