| Literature DB >> 9043657 |
T F Gallagher1, G L Seibel, S Kassis, J T Laydon, M J Blumenthal, J C Lee, D Lee, J C Boehm, S M Fier-Thompson, J W Abt, M E Soreson, J M Smietana, R F Hall, R S Garigipati, P E Bender, K F Erhard, A J Krog, G A Hofmann, P L Sheldrake, P C McDonnell, S Kumar, P R Young, J L Adams.
Abstract
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKC alpha and ERK kinase activity is observed.Entities:
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Year: 1997 PMID： 9043657 DOI： 10.1016/s0968-0896(96)00212-x
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641