OBJECTIVE: To investigate whether changes in the structure of the tunica albuginea influence the development of erectile dysfunction. PATIENTS AND METHODS: Biopsy specimens taken from the tunica of 64 patients (both potent and impotent) with and without Peyronie's disease were evaluated. Tissue samples were stained and examined under light and electron microscopy, and the concentration of elastic fibres present in each was measured using computerized image analysis. RESULTS: The concentration of elastic fibres was lower in impotent than in potent patients (P = 0.0365) and was also significantly less in patients with Peyronie's disease. Furthermore, the concentration of elastic fibres decreased with age. Electron and light microscopy revealed the presence of distinct alterations in the tunica albuginea in impotent patients and patients with Peyronie's disease that might interfere with function. CONCLUSION: The decrease in elastic fibre concentration and changes in microscopic features may contribute to erectile dysfunction by impairing the veno-occlusive function of the tunica albuginea.
OBJECTIVE: To investigate whether changes in the structure of the tunica albuginea influence the development of erectile dysfunction. PATIENTS AND METHODS: Biopsy specimens taken from the tunica of 64 patients (both potent and impotent) with and without Peyronie's disease were evaluated. Tissue samples were stained and examined under light and electron microscopy, and the concentration of elastic fibres present in each was measured using computerized image analysis. RESULTS: The concentration of elastic fibres was lower in impotent than in potent patients (P = 0.0365) and was also significantly less in patients with Peyronie's disease. Furthermore, the concentration of elastic fibres decreased with age. Electron and light microscopy revealed the presence of distinct alterations in the tunica albuginea in impotentpatients and patients with Peyronie's disease that might interfere with function. CONCLUSION: The decrease in elastic fibre concentration and changes in microscopic features may contribute to erectile dysfunction by impairing the veno-occlusive function of the tunica albuginea.
Authors: Josephine Hidalgo-Tamola; Ian Luttrell; Xiaogang Jiang; Dean Li; Robert P Mecham; Kanchan Chitaley Journal: J Sex Med Date: 2011-08-30 Impact factor: 3.802
Authors: Guiting Lin; Alan W Shindel; Lia Banie; Hongxiu Ning; Yun-Ching Huang; Gang Liu; Ching-Shwun Lin; Tom F Lue Journal: J Sex Med Date: 2010-04-01 Impact factor: 3.802
Authors: Alan W Shindel; Guiting Lin; Hongxiu Ning; Lia Banie; Yun-Ching Huang; Gang Liu; Ching-Shwun Lin; Tom F Lue Journal: J Sex Med Date: 2010-03-30 Impact factor: 3.802
Authors: Fernando S Carneiro; Lashon C Sturgis; Fernanda R C Giachini; Zidonia N Carneiro; Victor V Lima; Brandi M Wynne; Sebastian San Martin; Michael W Brands; Rita C Tostes; R Clinton Webb Journal: J Sex Med Date: 2009-01 Impact factor: 3.802