Literature DB >> 9042395

Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties.

B Gumusel1, Q Hao, A Hyman, J K Chang, D R Kapusta, H Lippton.   

Abstract

The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 x 10(-11)-3 x 10(-6) M) decreased tension in a concentration-dependent manner. The present data suggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow.

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Year:  1997        PMID： 9042395     DOI： 10.1016/s0024-3205(96)00696-0

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  Effects of nociceptin and nocistatin on antidromic vasodilatation in hairless skin of the rat hindlimb in vivo.

Authors:  H Häbler; L Timmermann; J Stegmann; W Jänig
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

Review 2.  How mental stress affects endothelial function.

Authors:  Noboru Toda; Megumi Nakanishi-Toda
Journal:  Pflugers Arch       Date:  2011-09-23       Impact factor: 3.657

Review 3.  Pharmacology of nociceptin and its receptor: a novel therapeutic target.

Authors:  G Calo'; R Guerrini; A Rizzi; S Salvadori; D Regoli
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Stimulation of sensory neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees.

Authors:  Chunfen Zhang; Jason J McDougall
Journal:  Br J Pharmacol       Date:  2006-06-19       Impact factor: 8.739

5.  Functional pharmacological characterization of SER100 in cardiovascular health and disease.

Authors:  Inmaculada C Villar; Kristen J Bubb; Amie J Moyes; Eva Steiness; Trygve Gulbrandsen; Finn Olav Levy; Adrian J Hobbs
Journal:  Br J Pharmacol       Date:  2016-11-01       Impact factor: 8.739

6.  ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries.

Authors:  U Simonsen; B E Laursen; J S Petersen
Journal:  Br J Pharmacol       Date:  2008-01-14       Impact factor: 8.739

Review 7.  Selected β2-, β3- and β2,3-Amino Acid Heterocyclic Derivatives and Their Biological Perspective.

Authors:  Urszula Bąchor; Marcin Mączyński
Journal:  Molecules       Date:  2021-01-15       Impact factor: 4.411

8.  Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile.

Authors:  Vinod Kumar; Willma E Polgar; Gerta Cami-Kobeci; Mark P Thomas; Taline V Khroyan; Lawrence Toll; Stephen M Husbands
Journal:  Front Psychiatry       Date:  2018-09-19       Impact factor: 4.157
  8 in total

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