Literature DB >> 9042225

Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.

A Andreani1, A Locatelli, M Rambaldi, A Leoni, R Bossa, A Fraccari, I Galatulas.   

Abstract

The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one unsubstituted NH group, are promising candidates for further investigation.

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Year:  1996        PMID： 9042225

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  4 in total

1.  Antitumor activity of bis-indole derivatives.

Authors:  Aldo Andreani; Silvia Burnelli; Massimiliano Granaiola; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Laura Landi; Cecilia Prata; Michael V Berridge; Carole Grasso; Heinz-Herbert Fiebig; Gerhard Kelter; Angelika M Burger; Mark W Kunkel
Journal:  J Med Chem       Date:  2008-07-04       Impact factor: 7.446

2.  Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

Authors:  Aldo Andreani; Stefania Bellini; Silvia Burnelli; Massimiliano Granaiola; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Natalia Calonghi; Concettina Cappadone; Maddalena Zini; Claudio Stefanelli; Lanfranco Masotti; Robert H Shoemaker
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

3.  Mitochondrial ribosomal small subunit (MRPS) MRPS23 protein-protein interaction reveals phosphorylation by CDK11-p58 affecting cell proliferation and knockdown of MRPS23 sensitizes breast cancer cells to CDK1 inhibitors.

Authors:  Revathi Paramasivam Oviya; Krishna Priya Thangaretnam; Balaji Ramachandran; Priya Ramanathan; Subramani Jayavelu; Gopisetty Gopal; Thangarajan Rajkumar
Journal:  Mol Biol Rep       Date:  2022-08-13       Impact factor: 2.742

4.  Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling.

Authors:  Jianjun Hu; Jie Lu; Gewei Lian; Jingping Zhang; Jonathan L Hecht; Volney L Sheen
Journal:  PLoS One       Date:  2014-02-14       Impact factor: 3.240
  4 in total

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