| Literature DB >> 9039040 |
E E Ladenheim1, J E Taylor, D H Coy, T S Carrigan, A Wohn, T H Moran.
Abstract
Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB-preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM-23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.Entities:
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Year: 1997 PMID： 9039040 DOI： 10.1152/ajpregu.1997.272.1.R433
Source DB: PubMed Journal: Am J Physiol ISSN： 0002-9513