Sertoli Leydig cell tumor with malignant heterologous elements and raised alpha-fetoprotein: a case report.

A case of a Sertoli Leydig cell tumor in a young female with virilizing symptoms and an androgenic endocrine profile with raised serum alpha-fetoprotein is presented. The tumor consisted predominantly of malignant epithelial and mesenchymal heterologous elements. Such a combination in the same tumor has to the best of our knowledge not been previously reported in English literature. The Leydig cells were immunohistochemically positive for alpha-fetoprotein. Sertoli Leydig cell tumors should be included in the differential diagnosis of tumors with raised alpha-fetoprotein. Chemotherapy in addition to surgery has been recommended for these tumors.