Literature DB >> 9037431

Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.

S Sato1, G T Gobbel, J Honkaniemi, Y Li, T Kondo, K Murakami, M Sato, J C Copin, P H Chan.   

Abstract

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

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Year:  1997        PMID： 9037431     DOI： 10.1016/s0006-8993(96)01231-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

Authors:  J N Keller; Q Guo; F W Holtsberg; A J Bruce-Keller; M P Mattson
Journal:  J Neurosci       Date:  1998-06-15       Impact factor: 6.167

2.  Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.

Authors:  D Pubill; E Verdaguer; A M Canudas; F X Sureda; E Escubedo; J Camarasa; M Pallàs; A Camins
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

3.  Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death.

Authors:  Sahabuddin Ahmed; Mohit Kwatra; Basveshwar Gawali; Samir Ranjan Panda; V G M Naidu
Journal:  Apoptosis       Date:  2020-11-23       Impact factor: 4.677

4.  Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.

Authors:  R T Matthews; L Yang; B G Jenkins; R J Ferrante; B R Rosen; R Kaddurah-Daouk; M F Beal
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

5.  Uncoupling oxidative/energy metabolism with low sub chronic doses of 3-nitropropionic acid or iodoacetate in vivo produces striatal cell damage.

Authors:  E Rodríguez; I Rivera; S Astorga; E Mendoza; F García; E Hernández-Echeagaray
Journal:  Int J Biol Sci       Date:  2010-04-22       Impact factor: 6.580

6.  Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders.

Authors:  Sidharth Mehan; Shaba Parveen; Sanjeev Kalra
Journal:  Neural Regen Res       Date:  2017-02       Impact factor: 5.135

Review 7.  3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.

Authors:  Isaac Túnez; Inmaculada Tasset; Verónica Pérez-De La Cruz; Abel Santamaría
Journal:  Molecules       Date:  2010-02-10       Impact factor: 4.411

8.  Effect of methotrexate exposure at late gestation on development of telencephalon in rat fetal brain.

Authors:  Ayano Hirako; Satoshi Furukawa; Takashi Takeuchi; Akihiko Sugiyama
Journal:  J Vet Med Sci       Date:  2015-09-13       Impact factor: 1.267
  8 in total

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