| Literature DB >> 9037311 |
S K Gupta1, A G Douglas-Jones, B Jasani, J M Morgan, M Pignatelli, R E Mansel.
Abstract
E-cadherin (E-cad) is an epithelial cell-cell adhesion molecule whose loss or reduced expression is associated with a more invasive tumour phenotype. Ninety-six cases of screen detected pure ductal carcinoma in situ (DCIS) were analysed immunocytochemically for expression of E-cad using the HECD-1 mouse monoclonal antibody. The in situ component in each case was classified on the basis of cytonuclear grade, extent of necrosis, Van Nuys classification and a newly devised Cardiff classification. The amount of E-cad expression was assessed semi-quantitatively using an intensity distribution method. There is significantly more expression of E-cad in well-differentiated DCIS when compared with poorly differentiated DCIS and this finding is highly significant (P < 0.001) irrespective of the classification system used. These findings suggest that progressive loss of E-cad expression may occur at an early stage of breast cancer development.Entities:
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Year: 1997 PMID： 9037311 DOI： 10.1007/bf01008012
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064