| Literature DB >> 9035375 |
M R Del Giudice1, A Borioni, C Mustazza, F Gatta, A Meneguz, M T Volpe.
Abstract
Some 6- and 7-methoxy-(and hydroxy-) tacrine derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. The most potent analogue in our series was the 9-heptylamino-6-methoxytacrine 3af which, in comparison with tacrine (THA), displayed an almost identical inhibitory effect, slightly lower acute toxicity and higher selectivity profile towards AchE when compared with THA.Entities:
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Year: 1996 PMID： 9035375
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X