Literature DB >> 9035141

Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity.

W Magliani1, S Conti, F de Bernardis, M Gerloni, D Bertolotti, P Mozzoni, A Cassone, L Polonelli.   

Abstract

Single chain fragment (ScFv) antiidiotypic antibodies (antilds) of a killer toxin (KT) from the yeast Pichia anomala have been produced by recombinant DNA methodology from the splenic lymphocytes of mice immunized by idiotypic vaccination with a KT-neutralizing monoclonal antibody (Mab KT4). ScFv KT-like antilds (KTIdAb) react with specific Candida albicans KT cell wall receptors (KTR) exerting a candidacidal activity in vitro could be neutralized by adsorption with Mab KT4. ScFv KTIdAb displayed an effective therapeutic activity in an experimental model of rat candidal vaginitis.

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Year:  1997        PMID： 9035141     DOI： 10.1038/nbt0297-155

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  28 in total

Review 1.  Yeast killer systems.

Authors:  W Magliani; S Conti; M Gerloni; D Bertolotti; L Polonelli
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

Review 2.  Immune defence against Candida fungal infections.

Authors:  Mihai G Netea; Leo A B Joosten; Jos W M van der Meer; Bart-Jan Kullberg; Frank L van de Veerdonk
Journal:  Nat Rev Immunol       Date:  2015-09-21       Impact factor: 53.106

3.  Inhibition of fungal beta-1,3-glucan synthase and cell growth by HM-1 killer toxin single-chain anti-idiotypic antibodies.

Authors:  Dakshnamurthy Selvakumar; Masahiko Miyamoto; Yasuhiro Furuichi; Tadazumi Komiyama
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

Review 4.  Anticandidal immunity and vaginitis: novel opportunities for immune intervention.

Authors:  Antonio Cassone; Flavia De Bernardis; Giorgio Santoni
Journal:  Infect Immun       Date:  2007-06-11       Impact factor: 3.441

5.  Production of an engineered killer peptide in Nicotiana benthamiana by using a potato virus X expression system.

Authors:  Marcello Donini; Chiara Lico; Selene Baschieri; Stefania Conti; Walter Magliani; Luciano Polonelli; Eugenio Benvenuto
Journal:  Appl Environ Microbiol       Date:  2005-10       Impact factor: 4.792

6.  Inhibitory effect of human natural yeast killer toxin-like candidacidal antibodies on Pneumocystis carinii.

Authors:  N Séguy; J C Cailliez; P Delcourt; S Conti; D Camus; E Dei-Cas; L Polonelli
Journal:  Mol Med       Date:  1997-08       Impact factor: 6.354

Review 7.  The protective role of immunoglobulins in fungal infections and inflammation.

Authors:  Sri Ramulu Elluru; Srini V Kaveri; Jagadeesh Bayry
Journal:  Semin Immunopathol       Date:  2014-11-18       Impact factor: 9.623

8.  Monoclonal immunoglobulin G1 directed against Aspergillus fumigatus cell wall glycoprotein protects against experimental murine aspergillosis.

Authors:  Ashok K Chaturvedi; A Kavishwar; G B Shiva Keshava; P K Shukla
Journal:  Clin Diagn Lab Immunol       Date:  2005-09

9.  A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities.

Authors:  María D Moragues; Miren J Omaetxebarria; Natalia Elguezabal; María J Sevilla; Stefania Conti; Luciano Polonelli; José Pontón
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

10.  Therapeutic activity of an engineered synthetic killer antiidiotypic antibody fragment against experimental mucosal and systemic candidiasis.

Authors:  Luciano Polonelli; Walter Magliani; Stefania Conti; Luisa Bracci; Luisa Lozzi; Paolo Neri; Daniela Adriani; Flavia De Bernardis; Antonio Cassone
Journal:  Infect Immun       Date:  2003-11       Impact factor: 3.441
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