Literature DB >> 9034615

Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation.

I Gorenne1, C Labat, J P Gascard, C Brink.   

Abstract

Human airways in vitro contract when stimulated by anti-IgE, whereas human pulmonary vessels relax. Leukotriene D4 (LTD4) induced a contractile response in the airways, while in pulmonary vessels both contractions and relaxations were observed. The LTD4 contractions in airways were blocked by cysLT1 receptor antagonists (MK 571, ICI 198615, and BAY x7195). In contrast none of the compounds affected the LTD4 contractions of pulmonary veins. These results suggest that the leukotrienes which are released during antigen challenge of airways and pulmonary vessels may be acting at distinct receptors in the human lung.

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Year:  1996        PMID： 9034615     DOI： 10.1007/bf00438152

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  10 in total

1.  The effect of indomethacin on immunologic release of histamine and sulfidopeptide leukotrienes from human bronchus and lung parenchyma.

Authors:  B J Undem; W C Pickett; L M Lichtenstein; G K Adams
Journal:  Am Rev Respir Dis       Date:  1987-11

2.  Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4.

Authors:  C K Buckner; R D Krell; R B Laravuso; D B Coursin; P R Bernstein; J A Will
Journal:  J Pharmacol Exp Ther       Date:  1986-05       Impact factor: 4.030

3.  Response to anti-human IgE in human pulmonary arteries. Regulation by endothelium.

Authors:  J L Ortiz; C Labat; X Norel; I Gorenne; J Verley; C Brink
Journal:  Am Rev Respir Dis       Date:  1993-04

4.  A second cysteinyl leukotriene receptor in human lung.

Authors:  C Labat; J L Ortiz; X Norel; I Gorenne; J Verley; T S Abram; N J Cuthbert; S R Tudhope; P Norman; P Gardiner
Journal:  J Pharmacol Exp Ther       Date:  1992-11       Impact factor: 4.030

5.  Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects.

Authors:  T Björck; S E Dahlén
Journal:  Pulm Pharmacol       Date:  1993-03

6.  Leukotriene receptors on human pulmonary vascular endothelium.

Authors:  J L Ortiz; I Gorenne; J Cortijo; A Seller; C Labat; B Sarria; T S Abram; P J Gardiner; E Morcillo; C Brink
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

7.  (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways.

Authors:  I Gorenne; C Labat; J P Gascard; X Norel; R Müller-Peddinghaus; K H Mohrs; W A Taylor; P J Gardiner; C Brink
Journal:  J Pharmacol Exp Ther       Date:  1994-02       Impact factor: 4.030

8.  Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

Authors:  B Samuelsson
Journal:  Science       Date:  1983-05-06       Impact factor: 47.728

9.  THE PHYSIOLOGY OF THE IMMEDIATE REACTION OF ANAPHYLAXIS IN THE GUINEA-PIG.

Authors:  J Auer; P A Lewis
Journal:  J Exp Med       Date:  1910-03-14       Impact factor: 14.307

10.  Anti-IgE Response in Human Airways: Relative Contribution of Inflammatory Mediators.

Authors:  I Gorenne; C Labat; X Norel; H S Alaoui; J P Gascard; C Brink
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711
  10 in total
  1 in total

1.  Is there a regulatory role of immunoglobulins on tissue forming cells relevant in chronic inflammatory lung diseases?

Authors:  Michael Roth
Journal:  J Allergy (Cairo)       Date:  2011-11-02
  1 in total

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