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Literature DB >> 9034593

Direct cell killing by suicide genes.

Abstract

Cell death can be induced by genetic intervention in a variety of ways. We review genetic prodrug activation therapies using both mammalian and non-mammalian enzyme systems as well as the expression of toxin genes and apoptotic triggers. Targeting of the genetic intervention using both transductional restriction and transcriptional control elements is examined in both in vitro and in vivo systems, and the present state of clinical trials is reviewed.

Entities: Species

Mesh：

Substances：
Prodrugs

Year: 1996 PMID： 9034593 DOI： 10.1007/bf00046344

Source DB: PubMed Journal: Cancer Metastasis Rev ISSN： 0167-7659 Impact factor: 9.264

70 in total

1. Genetic mechanisms of tumor suppression by the human p53 gene.

Authors: P L Chen; Y M Chen; R Bookstein; W H Lee
Journal: Science Date: 1990-12-14 Impact factor: 47.728

Review 2. The choice of prodrugs for gene directed enzyme prodrug therapy of cancer.

Authors: T A Connors
Journal: Gene Ther Date: 1995-12 Impact factor: 5.250

3. Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

Authors: H Schrewe; J Thompson; M Bona; L J Hefta; A Maruya; M Hassauer; J E Shively; S von Kleist; W Zimmermann
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

4. Modifications in the binding domain of avian retrovirus envelope protein to redirect the host range of retroviral vectors.

Authors: S Valsesia-Wittmann; A Drynda; G Deléage; M Aumailley; J M Heard; O Danos; G Verdier; F L Cosset
Journal: J Virol Date: 1994-07 Impact factor: 5.103

5. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Authors: S M Freeman; C N Abboud; K A Whartenby; C H Packman; D S Koeplin; F L Moolten; G N Abraham
Journal: Cancer Res Date: 1993-11-01 Impact factor: 12.701

6. Tissue-specific gene expression from Mo-MLV retroviral vectors with hybrid LTRs containing the murine tyrosinase enhancer/promoter.

Authors: R G Vile; R M Diaz; N Miller; S Mitchell; A Tuszyanski; S J Russell
Journal: Virology Date: 1995-12-01 Impact factor: 3.616

7. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

Authors: J M Bosher; T Williams; H C Hurst
Journal: Proc Natl Acad Sci U S A Date: 1995-01-31 Impact factor: 11.205

8. Gene therapy for cancer using tumour-specific prodrug activation.

Authors: J D Harris; A A Gutierrez; H C Hurst; K Sikora; N R Lemoine
Journal: Gene Ther Date: 1994-05 Impact factor: 5.250

9. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.

Authors: C A Mullen; M M Coale; R Lowe; R M Blaese
Journal: Cancer Res Date: 1994-03-15 Impact factor: 12.701

10. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

Authors: T Chittenden; C Flemington; A B Houghton; R G Ebb; G J Gallo; B Elangovan; G Chinnadurai; R J Lutz
Journal: EMBO J Date: 1995-11-15 Impact factor: 11.598

2 in total

1. The impact of γ-irradiation on the induction of bystander killing by genetically engineered ovarian tumor cells: implications for clinical use.

Authors: Jehad Zweiri; Stephen E Christmas
Journal: Cancer Cell Int Date: 2017-10-24 Impact factor: 5.722

2. Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics.

Authors: Jehad Zweiri; Stephen E Christmas
Journal: Cancer Cell Int Date: 2020-01-28 Impact factor: 5.722

2 in total