Literature DB >> 9034326

Mitochondrial DNA polymerases from yeast to man: a new family of polymerases.

N Lecrenier1, P Van Der Bruggen, F Foury.   

Abstract

We report the sequence of a 4.5-kb cDNA clone isolated from a human melanoma library which bears high amino acid sequence identity to the yeast mitochondrial (mt) DNA polymerase (Mip1p). This cDNA contains a 3720-bp open reading frame encoding a predicted 140-kDa polypeptide that is 43% identical to Mip1p. The N-terminal part of the sequence contains a 13 glutamine stretch encoded by a CAG trinucleotide repeat which is not found in the other DNA polymerases gamma (Pol gamma). Multiple amino acid sequence alignments with Pol gamma from Saccharomyces cerevisiae, Schizosaccharomyces pombe, Pichia pastoris, Drosophila melanogaster, Xenopus laevis and Mus musculus show that these DNA polymerases form a family strongly conserved from yeast to man and are only loosely related to the Family A DNA polymerases.

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Year:  1997        PMID： 9034326     DOI： 10.1016/s0378-1119(96)00663-4

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  21 in total

1.  Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase.

Authors:  J A Carrodeguas; D F Bogenhagen
Journal:  Nucleic Acids Res       Date:  2000-03-01       Impact factor: 16.971

2.  Nuclear genes that encode mitochondrial proteins for DNA and RNA metabolism are clustered in the Arabidopsis genome.

Authors:  Annakaisa Elo; Anna Lyznik; Delkin O Gonzalez; Stephen D Kachman; Sally A Mackenzie
Journal:  Plant Cell       Date:  2003-07       Impact factor: 11.277

3.  The polymorphic polyglutamine repeat in the mitochondrial DNA polymerase gamma gene is not associated with oligozoospermia.

Authors:  A Brusco; C Michielotto; V Gatta; C Foresta; G Matullo; M Zeviani; G Ferrari; E Dragone; G Calabrese; M Rossato; L Stuppia; N Migone
Journal:  J Endocrinol Invest       Date:  2006-01       Impact factor: 4.256

Review 4.  Mitochondria: in sickness and in health.

Authors:  Jodi Nunnari; Anu Suomalainen
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

Review 5.  Alpers-Huttenlocher syndrome.

Authors:  Russell P Saneto; Bruce H Cohen; William C Copeland; Robert K Naviaux
Journal:  Pediatr Neurol       Date:  2013-03       Impact factor: 3.372

Review 6.  Mitochondrial involvement in bladder function and dysfunction.

Authors:  C A Nevel-McGarvey; R M Levin; N Haugaard; X Wu; A P Hudson
Journal:  Mol Cell Biochem       Date:  1999-04       Impact factor: 3.396

7.  The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp.

Authors:  L Fan; P C Sanschagrin; L S Kaguni; L A Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

8.  The accessory subunit of Xenopus laevis mitochondrial DNA polymerase gamma increases processivity of the catalytic subunit of human DNA polymerase gamma and is related to class II aminoacyl-tRNA synthetases.

Authors:  J A Carrodeguas; R Kobayashi; S E Lim; W C Copeland; D F Bogenhagen
Journal:  Mol Cell Biol       Date:  1999-06       Impact factor: 4.272

Review 9.  Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.

Authors:  Ayman W El-Hattab; Fernando Scaglia
Journal:  Neurotherapeutics       Date:  2013-04       Impact factor: 7.620

Review 10.  Mitochondrial form and function.

Authors:  Jonathan R Friedman; Jodi Nunnari
Journal:  Nature       Date:  2014-01-16       Impact factor: 49.962
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