Literature DB >> 9034126

Replicative senescence and cell immortality: the role of telomeres and telomerase.

C P Chiu1, C B Harley.   

Abstract

Telomere shortening is correlated with cell senescence in vitro and cell aging in vivo. The telomere hypothesis suggests that telomere length serves as a mitotic clock for timing cellular replicative life span. Expression of telomerase stabilizes telomere length and allows for continual replication, or cell immortality. This article reviews recent evidences for the role of telomere length and telomerase in the regulation of cellular replicative life span. The therapeutic potential of manipulating telomerase expression and telomere length is also discussed.

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Year:  1997        PMID： 9034126     DOI： 10.3181/00379727-214-44075

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  27 in total

1.  IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28+ CD8 memory T cells throughout the adult age span.

Authors:  Huy Nguyen; Nan-ping Weng
Journal:  J Leukoc Biol       Date:  2009-10-01       Impact factor: 4.962

Review 2.  Regulation of the human catalytic subunit of telomerase (hTERT).

Authors:  Michael Daniel; Gregory W Peek; Trygve O Tollefsbol
Journal:  Gene       Date:  2012-02-13       Impact factor: 3.688

3.  Changes in telomere length distribution in low-dose X-ray-irradiated human umbilical vein endothelial cells.

Authors:  Jing-Zhi Guan; Wei Ping Guan; Toyoki Maeda; Naoki Makino
Journal:  Mol Cell Biochem       Date:  2014-07-25       Impact factor: 3.396

4.  Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA.

Authors:  M S Fitzgerald; K Riha; F Gao; S Ren; T D McKnight; D E Shippen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

5.  CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.

Authors:  Wangbing Chen; Lijun Qin; Shusen Wang; Mei Li; Dingbo Shi; Yun Tian; Jingshu Wang; Lingyi Fu; Zhenglin Li; Wei Guo; Wendan Yu; Yuhui Yuan; Tiebang Kang; Wenlin Huang; Wuguo Deng
Journal:  Mol Oncol       Date:  2014-02-14       Impact factor: 6.603

6.  Value of endoscopic methylene blue and Lugol's iodine double staining and detection of GST-Pi and telomerase in the early diagnosis of esophageal carcinoma.

Authors:  Xuan Zhu; Shuang-Hong Zhang; Kun-He Zhang; Bi-Ming Li; Jiang Chen
Journal:  World J Gastroenterol       Date:  2005-10-21       Impact factor: 5.742

7.  Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression.

Authors:  Se-Lyun Yoon; Se-Il Jung; Eun-Ju Do; Se-Ra Lee; Sang-Yeop Lee; In-Sun Chu; Wun-Jae Kim; Jaeil Jung; Choung Soo Kim; Sang-Hyeon Cheon; Sun-Hee Leem
Journal:  BMC Cancer       Date:  2010-07-26       Impact factor: 4.430

8.  Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.

Authors:  Polina Iakova; Guo-Li Wang; Lubov Timchenko; Marek Michalak; Olivia M Pereira-Smith; James R Smith; Nikolai A Timchenko
Journal:  EMBO J       Date:  2004-01-15       Impact factor: 11.598

9.  K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts.

Authors:  Subhashinee S K Wijeratne; Gabriela Camporeale; Janos Zempleni
Journal:  J Nutr Biochem       Date:  2009-04-14       Impact factor: 6.048

10.  Expression of VEGF, HGF, IL-6, IL-8, MMP-9, Telomerase in Peripheral Blood of Patients with Head and Neck Squamous Cell Carcinoma.

Authors:  Dae-Young Hong; Byung-Joo Lee; Jin-Choon Lee; Jin-Sik Choi; Soo-Geun Wang; Jung-Hoon Ro
Journal:  Clin Exp Otorhinolaryngol       Date:  2009-12-31       Impact factor: 3.372
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