Waldenström's macroglobulinemia associated with glioblastoma. A case report.

Waldenström Macroglobulinemia (WM) involves the Central Nervous System in about 10% of the affected patients, but only occasionally related clinical and histopathological changes have been considered. Most of the published papers focus on leptomeningeal lymphoplasmacytic infiltrates, even though the damage to the CNS results in a more variegated scenario. Association to a malignant neoplasm, usually of lymphoid series, is not uncommon, instead association with a glioblastoma is rare, and only 3 cases have been reported. Despite the rarity of this finding, the association Waldenström Macroglobulinemia-glioblastoma may not be coincidental. Probable etiopathological links are thereby discussed.