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Literature DB >> 903363

Covalent structure of the beta chain of cholera enterotoxin.

Abstract

The complete amino acid sequence of the beta chain of cholera enterotoxin was determined: NH2-Thr-Pro-Gln-Asn-Ile-Thr-Asp-Leu-Cys-Ala-Glu-Tyr-His-Asn-Thr-Gln-Ile-His-Thr-Leu-Asn-Asn-Lys-Ile-Phe-Ser-Tyr-Thr-Glu-Ser-Leu-Ala-Gly-Lys-Arg-Glu-Met-Ala-Ile-Ile-Thr-Phe-Lys-Asn-Gly-Ala-Thr-Phe-Gln-Val-Glu-Val-Pro-Gly-Ser-Gln-His-Ile-Asp-Ser-Gln-Lys-Lys-Ala-Ile-Glu-Arg-Met-Lys-Asn-Thr-Leu-Arg-Ile-Ala-Tyr-Leu-Thr-Glu-Ala-Lys-Val-Glu-Lys-Leu-Cys-Val-Trp-Asn-Asn-Lys-Thr-Pro-His-Ala-Ile-Ala-Ala-Ile-Ser-Met- Ala-Asn-COOH. The sequence was obtained from automated sequence analysis of intact beta chain, cyanogen bromide fragments, and a fragment generated by cleavage at a single tryptophan with 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine as well as from manual sequence analysis of tryptic peptides using 5-dimethylaminonaphthalene-1-sulfonyl-monitored Edman methodology. The tryptic peptides accounted for all 103 residues established for the complete primary structure.

Entities: Chemical

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Year: 1977 PMID： 903363

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

17 in total

1. Activation of cholera toxin-specific T cells in vitro.

Authors: C O Elson; S Solomon
Journal: Infect Immun Date: 1990-11 Impact factor: 3.441

2. Studies on the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin.

Authors: J Fischer; T R Kohler; L G Lipson; J Flores; P A Witkum; G W Sharp
Journal: Biochem J Date: 1978-07-01 Impact factor: 3.857

3. Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

Authors: J Sanchez; J Holmgren
Journal: Proc Natl Acad Sci U S A Date: 1989-01 Impact factor: 11.205

4. Two-dimensional crystals of cholera toxin B-subunit-receptor complexes: projected structure at 17-A resolution.

Authors: D S Ludwig; H O Ribi; G K Schoolnik; R D Kornberg
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

5. Protection against experimental cholera by oral or parenteral immunization.

Authors: J W Peterson
Journal: Infect Immun Date: 1979-11 Impact factor: 3.441

Review 6. Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.

Authors: K L Richards; S D Douglas
Journal: Microbiol Rev Date: 1978-09

Covalent structure of the beta chain of cholera enterotoxin.

1. Activation of cholera toxin-specific T cells in vitro.

2. Studies on the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin.

3. Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.

4. Two-dimensional crystals of cholera toxin B-subunit-receptor complexes: projected structure at 17-A resolution.

5. Protection against experimental cholera by oral or parenteral immunization.

Review 6. Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells.

7. Human glutathione S-transferases. Characterization of the anionic forms from lung and placenta.

8. Glutathione S-transferases of human brain. Evidence for two immunologically distinct types of 26500-Mr subunits.

9. Immunological characterization of a human homolog of the 65-kilodalton mycobacterial antigen.

10. Anti-idiotypic antibodies as probes of protein active sites: application to cholera toxin subunit B.