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Literature DB >> 9033596

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.

M Hirshberg¹, R W Stockley, G Dodson, M R Webb.

Abstract

The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.

Entities: Chemical Gene Species

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Year: 1997 PMID： 9033596 DOI： 10.1038/nsb0297-147

Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368

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Cited

55 in total

1. Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.

Authors: S Datta; M M Prabu; M B Vaze; N Ganesh; N R Chandra; K Muniyappa; M Vijayan
Journal: Nucleic Acids Res Date: 2000-12-15 Impact factor: 16.971

2. The insert region of Rac1 is essential for membrane ruffling but not cellular transformation.

Authors: A E Karnoub; C J Der; S L Campbell
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

3. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.

Authors: H G Vikis; W Li; Z He; K L Guan
Journal: Proc Natl Acad Sci U S A Date: 2000-11-07 Impact factor: 11.205

4. Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.

Authors: V M Braga; M Betson; X Li; N Lamarche-Vane
Journal: Mol Biol Cell Date: 2000-11 Impact factor: 4.138

9. Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.

Authors: Y Horiguchi; N Inoue; M Masuda; T Kashimoto; J Katahira; N Sugimoto; M Matsuda
Journal: Proc Natl Acad Sci U S A Date: 1997-10-14 Impact factor: 11.205

10. Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.

Authors: S Bouguet-Bonnet; M Buck
Journal: J Mol Biol Date: 2008-02-04 Impact factor: 5.469

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue.

1. Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.

2. The insert region of Rac1 is essential for membrane ruffling but not cellular transformation.

3. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.

4. Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.

5. The insert region of RhoA is essential for Rho kinase activation and cellular transformation.

6. The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase.

7. Identification of protein functions from a molecular surface database, eF-site.

8. Rapid evolution in conformational space: a study of loop regions in a ubiquitous GTP binding domain.

9. Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.

10. Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.