| Literature DB >> 9032939 |
M Venugopal1, J M Jamison, J Gilloteaux, J A Koch, M Summers, J Hoke, C Sowick, J L Summers.
Abstract
Vitamins C, K3 (VC, VK3) and a VC/VK3 combination with a VC:VK3 ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co-administration of the vitamins enhanced the antitumour activity 5- to 20-fold even with a 1 h exposure time. While exogenous catalase destroyed the antitumour activity, hydrogen peroxide-induced lipid peroxidation was negligible. Analysis of cellular ATP and thiol levels as well as DNA and protein synthesis revealed: a transient increase in ATP production, a decrease in DNA synthesis, an increase in protein synthesis and a decrease in thiol levels. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.Entities:
Mesh：
Substances：
Year: 1996 PMID： 9032939 DOI： 10.1006/cbir.1996.0102
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612