Literature DB >> 9032399

The herpesvirus saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases.

A Whitehouse1, I M Carr, J C Griffiths, D M Meredith.   

Abstract

The mRNA species encoding the herpesvirus saimiri (HVS) homolog of the Epstein-Barr virus R transcriptional activator (termed ORF50) have been identified and used to determine transcriptional start sites within the gene. The first transcript is spliced and starts from a promoter within ORF49 containing a single intron; the second is produced from a promoter within the second exon and is in the same reading frame. The spliced transcript is detected at early times during productive virus replication in OMK cells, whereas the nonspliced transcript is detected later. The spliced transcript is fivefold-more potent in activating the delayed-early ORF6 promoter; the function of the nonspliced transcript is unclear. Thus, the role of this protein in activating herpesvirus saimiri from the latent state may differ significantly from that of the Epstein-Barr virus R protein.

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Year:  1997        PMID： 9032399      PMCID： PMC191372     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  28 in total

1.  The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16.

Authors:  J M Hardwick; L Tse; N Applegren; J Nicholas; M A Veliuona
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

2.  Conservation of gene organization in the lymphotropic herpesviruses herpesvirus Saimiri and Epstein-Barr virus.

Authors:  U A Gompels; M A Craxton; R W Honess
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

3.  Mapping of herpesvirus saimiri proteins on the viral genome: proteins dependent and not dependent on viral DNA synthesis.

Authors:  W Hell; S Modrow; H Wolf
Journal:  J Virol       Date:  1985-11       Impact factor: 5.103

4.  Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

Authors:  R W Honess; B Roizman
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

5.  Proteins specified by herpesvirus saimiri: identification and properties of virus-specific polypeptides in productively infected cells.

Authors:  R E Randall; R W Honess; P O'Hare
Journal:  J Gen Virol       Date:  1983-01       Impact factor: 3.891

6.  The complete DNA sequence of varicella-zoster virus.

Authors:  A J Davison; J E Scott
Journal:  J Gen Virol       Date:  1986-09       Impact factor: 3.891

7.  A single major immediate-early virus gene product is synthesized in cells productively infected with herpesvirus saimiri.

Authors:  R E Randall; C Newman; R W Honess
Journal:  J Gen Virol       Date:  1984-07       Impact factor: 3.891

8.  Cloning of Herpesvirus saimiri DNA fragments representing the entire L-region of the genome.

Authors:  E Knust; S Schirm; W Dietrich; W Bodemer; E Kolb; B Fleckenstein
Journal:  Gene       Date:  1983-11       Impact factor: 3.688

9.  A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen.

Authors:  J M Hardwick; P M Lieberman; S D Hayward
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

Review 10.  The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.

Authors:  D J McGeoch; M A Dalrymple; A J Davison; A Dolan; M C Frame; D McNab; L J Perry; J E Scott; P Taylor
Journal:  J Gen Virol       Date:  1988-07       Impact factor: 3.891
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  31 in total

1.  The open reading frame 57 gene product of herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export.

Authors:  D J Goodwin; K T Hall; A J Stevenson; A F Markham; A Whitehouse
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication.

Authors:  Iglika V Pavlova; Herbert W Virgin; Samuel H Speck
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

3.  The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32.

Authors:  Kersten T Hall; Mathew S Giles; Michael A Calderwood; Delyth J Goodwin; David A Matthews; Adrian Whitehouse
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

4.  The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters.

Authors:  Matthew S Walters; Kersten T Hall; Adrian Whitehouse
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

5.  The activation domain of herpesvirus saimiri R protein interacts with the TATA-binding protein.

Authors:  K T Hall; A J Stevenson; D J Goodwin; P C Gibson; A F Markham; A Whitehouse
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

6.  Lytic cycle gene regulation of Epstein-Barr virus.

Authors:  Wolfgang Amon; Ulrich K Binné; Helen Bryant; Peter J Jenkins; Claudio Elgueta Karstegl; Paul J Farrell
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

7.  Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNA.

Authors:  Pey-Jium Chang; Duane Shedd; George Miller
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

8.  Marked variation in response of consensus binding elements for the Rta protein of Epstein-Barr virus.

Authors:  Lee-Wen Chen; Pey-Jium Chang; Henri-Jacques Delecluse; George Miller
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

9.  Two phenylalanines in the C-terminus of Epstein-Barr virus Rta protein reciprocally modulate its DNA binding and transactivation function.

Authors:  Lee-Wen Chen; Vineetha Raghavan; Pey-Jium Chang; Duane Shedd; Lee Heston; Henri-Jacques Delecluse; George Miller
Journal:  Virology       Date:  2009-02-15       Impact factor: 3.616

10.  Kinetics of expression of rhesus monkey rhadinovirus (RRV) and identification and characterization of a polycistronic transcript encoding the RRV Orf50/Rta, RRV R8, and R8.1 genes.

Authors:  Scott M DeWire; Michael A McVoy; Blossom Damania
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103
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