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Literature DB >> 9032283

Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription.

E J Schwarz¹, M J Reginato, D Shao, S L Krakow, M A Lazar.

Abstract

Adipocyte differentiation is thought to involve sequential induction of the transcription factors C/EBPbeta, peroxisome proliferator-activated receptor gamma (PPARgamma), and C/EBPalpha. C/EBPalpha expression is both necessary and sufficient for adipocyte differentiation. Here we report that ectopic expression of either C/EBPalpha or C/EBPbeta induces PPARgamma expression and adipogenesis and that retinoic acid (RA) completely inhibits adipogenesis by either form of C/EBP. In studies of normal preadipocytes, RA does not prevent C/EBPbeta induction but blocks induction of PPARgamma, C/EBPalpha, and adipogenesis. In transient transfection studies, liganded RA receptor (RAR) specifically blocks transcriptional activation by either C/EBPalpha or C/EBPbeta. These results strongly suggest that C/EBPalpha substitutes for C/EBPbeta to induce adipocyte differentiation and that liganded RAR inhibits adipogenesis by blocking C/EBPbeta-mediated induction of downstream genes.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1997 PMID： 9032283 PMCID： PMC231881 DOI： 10.1128/MCB.17.3.1552

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

72 in total

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6. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.

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7. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

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Journal: Cell Date: 1995-12-01 Impact factor: 41.582

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9. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.

Authors: Y Kamei; L Xu; T Heinzel; J Torchia; R Kurokawa; B Gloss; S C Lin; R A Heyman; D W Rose; C K Glass; M G Rosenfeld
Journal: Cell Date: 1996-05-03 Impact factor: 41.582

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Authors: S Akira; H Isshiki; T Sugita; O Tanabe; S Kinoshita; Y Nishio; T Nakajima; T Hirano; T Kishimoto
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101 in total

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Review 5. Transcriptional control of adipocyte formation.

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6. Bifunctional role of Rev-erbalpha in adipocyte differentiation.

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Review 7. Retinoic acid signaling pathways in development and diseases.

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