Literature DB >> 9031666

TMC-1 A, B, C and D, new antibiotics of the manumycin group produced by Streptomyces sp. Taxonomy, production, isolation, physico-chemical properties, structure elucidation and biological properties.

J Kohno1, M Nishio, K Kawano, N Nakanishi, S Suzuki, T Uchida, S Komatsubara.   

Abstract

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

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Year:  1996        PMID： 9031666     DOI： 10.7164/antibiotics.49.1212

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Manumycin polyketides act as molecular glues between UBR7 and P53.

Authors:  Yosuke Isobe; Mikiko Okumura; Lynn M McGregor; Scott M Brittain; Michael D Jones; Xiaoyou Liang; Ross White; William Forrester; Jeffrey M McKenna; John A Tallarico; Markus Schirle; Thomas J Maimone; Daniel K Nomura
Journal:  Nat Chem Biol       Date:  2020-06-22       Impact factor: 15.040

2.  Identification of Antimicrobial Compounds in Two Streptomyces sp. Strains Isolated From Beehives.

Authors:  Fernando Santos-Beneit; Ana Ceniceros; Athanasios Nikolaou; José A Salas; Jorge Gutierrez-Merino
Journal:  Front Microbiol       Date:  2022-02-03       Impact factor: 5.640

3.  Stereoselectively synthesis and structural confirmation of dehydrodipeptides with dehydrobutyrine.

Authors:  Xia Tian; Linna Li; Jianrong Han; Xiaoli Zhen; Shouxin Liu
Journal:  Springerplus       Date:  2016-04-01

4.  Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.

Authors:  Aida Sarmiento-Vizcaíno; Julia Espadas; Jesús Martín; Alfredo F Braña; Fernando Reyes; Luis A García; Gloria Blanco
Journal:  Front Microbiol       Date:  2018-04-23       Impact factor: 5.640

5.  Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes.

Authors:  Shun Saito; Kanji Indo; Naoya Oku; Hisayuki Komaki; Masashi Kawasaki; Yasuhiro Igarashi
Journal:  Beilstein J Org Chem       Date:  2021-12-16       Impact factor: 2.883
  5 in total

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