Literature DB >> 9031664

New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

H Nakajima1, B Sato, T Fujita, S Takase, H Terano, M Okuhara.   

Abstract

New antitumor substances, FR901463, FR901464 and FR901465 were isolated from the culture broth of a bacterium of Pseudomonas sp. No.2663. FR901463, FR901464 and FR901465 remarkably enhanced the transcriptional activity of the promoter of SV40 DNA virus. Further, these compounds exhibited potent antitumor activities against murine and human tumor cell lines in vitro.

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Year:  1996        PMID： 9031664     DOI： 10.7164/antibiotics.49.1196

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  64 in total

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5.  Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue.

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Review 8.  Genome-guided discovery of diverse natural products from Burkholderia sp.

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