| Literature DB >> 9031101 |
C A Smith1, C Y Ng, S K Loftin, C Li, H E Heslop, M K Brenner, C M Rooney.
Abstract
Epstein-Barr virus (EBV) causes opportunistic B cell lymphomas in patients whose cellular immunity is compromised. We have been investigating whether infusions of donor-derived, EBV-specific cytotoxic T cells can prevent and/or treat EBV-related lymphoproliferative disease in children receiving T cell-depleted bone marrow from HLA-matched, unrelated or HLA-mismatched, related donors. In this review, we discuss the rationale for this therapeutic approach, describe our experiences with the regimen thus far, and consider some future directions in immunotherapy.Entities:
Mesh：
Year: 1996 PMID： 9031101 DOI： 10.3109/10428199609054823
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022