| Literature DB >> 9030974 |
O Muraoka1, H Tanaka, M Itoh, K Ishihara, T Hirano.
Abstract
BST-1 is an ectoenzyme expressed on human bone marrow Stromal cells and myeloid lineage cells, having both ADP-ribosyl cyclase and cyclic ADP-ribose (cADPR) hydrolase activities. In mouse, BST-1 is also expressed on lymphoid progenitors. We isolated chromosomal DNA segments of the human BST-1 gene. The human BST-1 gene consisted of nine exons and eight introns. The length of each exon was very similar to that of the Aplysia ADP-ribosyl cyclase gene. The flanking region of the BST-1 gene contained several potential binding sites for nuclear factors, NF-kappa B, p53, NF-IL6, CREB, PEA3, E2A, C/EBP, AP3, AP2 and SP1 and consensus sequences for gamma-IRE and ISRE like element.Entities:
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Year: 1996 PMID： 9030974 DOI： 10.1016/s0165-2478(96)02633-8
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685