Literature DB >> 9028044

Protection by trehalose of DNA from radiation damage.

K Yoshinaga1, H Yoshioka, H Kurosaki, M Hirasawa, M Uritani, K Hasegawa.   

Abstract

The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mM trehalose, DNA can be protected from about 4 times higher doses of beta- and gamma-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.

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Year:  1997        PMID： 9028044     DOI： 10.1271/bbb.61.160

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  18 in total

1.  Tailoring Trehalose for Biomedical and Biotechnological Applications.

Authors:  Mara K O'Neill; Brent F Piligian; Claire D Olson; Peter J Woodruff; Benjamin M Swarts
Journal:  Pure Appl Chem       Date:  2017-01-11       Impact factor: 2.453

2.  Genetic background of enhanced radioresistance in an anhydrobiotic insect: transcriptional response to ionizing radiations and desiccation.

Authors:  Alina Ryabova; Kyosuke Mukae; Alexander Cherkasov; Richard Cornette; Elena Shagimardanova; Tetsuya Sakashita; Takashi Okuda; Takahiro Kikawada; Oleg Gusev
Journal:  Extremophiles       Date:  2016-11-02       Impact factor: 2.395

3.  Inelastic neutron scattering study on bioprotectant systems.

Authors:  S Magazù; F Migliardo; A J Ramirez-Cuesta
Journal:  J R Soc Interface       Date:  2005-12-22       Impact factor: 4.118

4.  Trehalose accumulation and radiation resistance due to prior heat stress in Saccharomyces cerevisiae.

Authors:  Ryoko Asada; Takeru Watanabe; Yoshiharu Tanaka; Masao Kishida; Masakazu Furuta
Journal:  Arch Microbiol       Date:  2022-04-22       Impact factor: 2.552

5.  Exogenously-supplied trehalose inhibits the growth of wheat seedlings under high temperature by affecting plant hormone levels and cell cycle processes.

Authors:  Yin Luo; Xueying Liu; Weiqiang Li
Journal:  Plant Signal Behav       Date:  2021-05-07

6.  Classes of Drugs that Mitigate Radiation Syndromes.

Authors:  Ewa D Micewicz; Robert D Damoiseaux; Gang Deng; Adrian Gomez; Keisuke S Iwamoto; Michael E Jung; Christine Nguyen; Andrew J Norris; Josephine A Ratikan; Piotr Ruchala; James W Sayre; Dörthe Schaue; Julian P Whitelegge; William H McBride
Journal:  Front Pharmacol       Date:  2021-05-18       Impact factor: 5.810

7.  Anhydrobiosis-associated nuclear DNA damage and repair in the sleeping chironomid: linkage with radioresistance.

Authors:  Oleg Gusev; Yuichi Nakahara; Veronica Vanyagina; Ludmila Malutina; Richard Cornette; Tetsuya Sakashita; Nobuyuki Hamada; Takahiro Kikawada; Yasuhiko Kobayashi; Takashi Okuda
Journal:  PLoS One       Date:  2010-11-16       Impact factor: 3.240

8.  Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography.

Authors:  Erhan Bat; Juneyoung Lee; Uland Y Lau; Heather D Maynard
Journal:  Nat Commun       Date:  2015-03-20       Impact factor: 14.919

9.  Functionality and prevalence of trehalose-based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi.

Authors:  Timon T Wyatt; M Richard van Leeuwen; Elena A Golovina; Folkert A Hoekstra; Eric J Kuenstner; Edward A Palumbo; Nicole L Snyder; Cobus Visagie; Alex Verkennis; John E Hallsworth; Han A B Wösten; Jan Dijksterhuis
Journal:  Environ Microbiol       Date:  2014-10-22       Impact factor: 5.491

10.  Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.

Authors:  Aprotim Mazumder; Laia Quiros Pesudo; Siobhan McRee; Mark Bathe; Leona D Samson
Journal:  Nucleic Acids Res       Date:  2013-08-09       Impact factor: 16.971
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