Literature DB >> 9027788

Pharmacokinetics of carboplatin and etoposide in a haemodialysis patient with Merkel-cell carcinoma.

S Suzuki1, M Koide, S Sakamoto, T Matsuo.   

Abstract

We present a Merkel-cell carcinoma patient with chronic renal failure requiring haemodialysis and evaluate the pharmacokinetics of carboplatin and etoposide during haemodialysis. The area under the concentration-time curve of carboplatin was increased by prolonging the interval between administration and haemodialysis. However, that of etoposide was not changed. Carboplatin showed good membrane permeability in haemodialysis, while etoposide showed no permeability. In conclusion, the pharmacokinetics of carboplatin could be controlled by haemodialysis and the interval between chemotherapy and haemodialysis. However, the pharmacokinetics of etoposide were not affected.

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Year:  1997        PMID： 9027788     DOI： 10.1093/ndt/12.1.137

Source DB:  PubMed          Journal:  Nephrol Dial Transplant        ISSN： 0931-0509            Impact factor:   5.992


  7 in total

Review 1.  Effect of haemodialysis on the pharmacokinetics of antineoplastic drugs.

Authors:  Masatoshi Tomita; Yoichi Aoki; Kenichi Tanaka
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

2.  Dose adjustment of carboplatin in patients on hemodialysis.

Authors:  Achuta K Guddati; Parijat S Joy; Creticus P Marak
Journal:  Med Oncol       Date:  2014-01-23       Impact factor: 3.064

3.  Continuous ambulatory peritoneal dialysis: pharmacokinetics and clinical outcome of paclitaxel and carboplatin treatment.

Authors:  Joan B Heijns; Maria E L van der Burg; Teun van Gelder; Marien W J A Fieren; Peter de Bruijn; Ate van der Gaast; Walter J Loos
Journal:  Cancer Chemother Pharmacol       Date:  2008-01-19       Impact factor: 3.333

4.  Pharmacokinetic analyses of carboplatin in a patient with cancer of the fallopian tubes undergoing hemodialysis: A case report.

Authors:  Takuma Wada; Takeshi Fukuda; Masaru Kawanishi; Reiko Tasaka; Kenji Imai; Makoto Yamauchi; Mari Kasai; Yasunori Hashiguchi; Tomoyuki Ichimura; Tomoyo Yasui; Toshiyuki Sumi
Journal:  Biomed Rep       Date:  2016-07-04

5.  Carboplatin pharmacokinetics in a patient receiving hemodialysis.

Authors:  Mei Ka Fong; Gerald J Fetterly; Lori J McDougald; Renuka V Iyer
Journal:  Pharmacotherapy       Date:  2013-09-14       Impact factor: 4.705

6.  Investigation of tolerability and quality of life for carboplatin-based chemotherapy in an elderly urothelial carcinoma patient undergoing hemodialysis: a case report.

Authors:  Masahiro Kondo; Taku Naiki; Yuji Hotta; Yuko Yamamoto; Yosuke Sugiyama; Takahiro Yasui; Kazunori Kimura
Journal:  J Pharm Health Care Sci       Date:  2018-11-29

Review 7.  Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure.

Authors:  Kenichi Fujita; Natsumi Matsumoto; Hiroo Ishida; Yutaro Kubota; Shinichi Iwai; Motoko Shibanuma; Yukio Kato
Journal:  Curr Drug Metab       Date:  2019       Impact factor: 3.731
  7 in total

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