Literature DB >> 9026378

TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats.

A Kagaya1, A J Tanra, H Shinno, A Kugaya, M Muraoka, T Oyamada, Y Uchitomi, S Yamawaki.   

Abstract

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (+/-)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by 0.1 mg/kg 8-OH-DPAT was enhanced by 500 and 750 mg/kg of TJS-010. At the concentration of 0.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750 mg/kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

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Year:  1996        PMID： 9026378     DOI： 10.1007/BF01292617

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

Review 1.  Oriental medicine as therapy for resistant depression: use of some herbal drugs in the far east (Japan).

Authors:  K Sarai
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1992-03       Impact factor: 5.067

2.  Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat.

Authors:  M D Tricklebank; D N Middlemiss; J Neill
Journal:  Neuropharmacology       Date:  1986-08       Impact factor: 5.250

Review 3.  Azaspirodecanediones in generalized anxiety disorder: buspirone.

Authors:  A Ortiz; R Pohl; S Gershon
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4.  Clinical profile of gepirone, a nonbenzodiazepine anxiolytic.

Authors:  N E Harto; R J Branconnier; K F Spera; E C Dessain
Journal:  Psychopharmacol Bull       Date:  1988

5.  Saireito (a Chinese herbal drug)-stimulated secretion and synthesis of pituitary ACTH are mediated by hypothalamic corticotropin-releasing factor.

Authors:  Y Nakano; T Suda; F Tozawa; I Dobashi; Y Sato; N Ohmori; T Sumitomo; H Demura
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6.  Analysis of individual symptoms in generalized anxiety--a pooled, multistudy, double-blind evaluation of buspirone.

Authors:  J P Feighner; J B Cohn
Journal:  Neuropsychobiology       Date:  1989       Impact factor: 2.328

7.  Gepirone in anxiety: a pilot study.

Authors:  I Csanalosi; E Schweizer; W G Case; K Rickels
Journal:  J Clin Psychopharmacol       Date:  1987-02       Impact factor: 3.153

8.  5-HT1A receptor-effector system responsivity in panic disorder.

Authors:  K P Lesch; M Wiesmann; A Hoh; T Müller; J Disselkamp-Tietze; M Osterheider; H M Schulte
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

9.  Long-term treatment of anxiety and risk of withdrawal. Prospective comparison of clorazepate and buspirone.

Authors:  K Rickels; E Schweizer; I Csanalosi; W G Case; H Chung
Journal:  Arch Gen Psychiatry       Date:  1988-05

Review 10.  Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.

Authors:  K L Goa; A Ward
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546
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