| Literature DB >> 9025258 |
M Grigorov1, J Weber, J M Tronchet, C W Jefford, W K Milhous, D Maric.
Abstract
The antimalarial activity of a series of synthetic 1,2,4-trioxanes is correlated with molecular structure by using a pharmacophore search method (CATALYST). The technique is shown to have predictive accuracy and confirms that docking between an active trioxane and the receptor, heme, is the crucial step for drug action.Entities:
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Year: 1997 PMID： 9025258 DOI： 10.1021/ci9601168
Source DB: PubMed Journal: J Chem Inf Comput Sci ISSN： 0095-2338