Literature DB >> 9022288

Bone morphogenic protein-4.

L M Leong1, P M Brickell.   

Abstract

Bone morphogenic protein-4 (BMP-4) is one of nine structurally related BMPs belonging to the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. Although discovered because it stimulates bone formation in adult mammals, BMP-4 has important roles as a signalling molecule in embryonic tissues, including the developing central and peripheral nervous system, musculature and skeleton. It participates in an ancient signalling pathway also found in insects and worms. Nevertheless, the main practical application of BMPs is for stimulating repair of bone, and their use in humans is currently being assessed.

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Year:  1996        PMID： 9022288     DOI： 10.1016/s1357-2725(96)00075-1

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  8 in total

1.  Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.

Authors:  Eva-Maria Duerr; Yusuke Mizukami; Kentaro Moriichi; Manish Gala; Won-Seok Jo; Hirotoshi Kikuchi; Ramnik J Xavier; Daniel C Chung
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-03-01       Impact factor: 4.052

2.  Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.

Authors:  Ji-Youn Youn; Jun Zhou; Hua Cai
Journal:  Mol Endocrinol       Date:  2015-06-29

3.  A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells.

Authors:  N Olsen; T Sokka; C L Seehorn; B Kraft; K Maas; J Moore; T M Aune
Journal:  Ann Rheum Dis       Date:  2004-11       Impact factor: 19.103

4.  Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation.

Authors:  Weiwei Yin; Hanjoong Jo; Eberhard O Voit
Journal:  Ann Biomed Eng       Date:  2009-10-23       Impact factor: 3.934

5.  Bone morphogenetic proteins (BMPs) expression in the femoral heads of patients with avascular necrosis.

Authors:  Stavroula Samara; Zoe Dailiana; Sokratis Varitimidis; Christos Chassanidis; Theodora Koromila; Konstantinos N Malizos; Panagoula Kollia
Journal:  Mol Biol Rep       Date:  2013-05-07       Impact factor: 2.316

6.  Solubilization and renaturation of biologically active human bone morphogenetic protein-4 from inclusion bodies.

Authors:  Gesa-Maria Gieseler; Kimia Ekramzadeh; Volker Nölle; Svitlana Malysheva; Henning Kempf; Sascha Beutel; Robert Zweigerdt; Ulrich Martin; Ursula Rinas; Thomas Scheper; Iliyana Pepelanova
Journal:  Biotechnol Rep (Amst)       Date:  2018-04-04

7.  Preliminary Analysis of the Nonsynonymous Polymorphism rs17563 in BMP4 Gene in Brazilian Population Suggests Protection for Nonsyndromic Cleft Lip and Palate.

Authors:  Tânia Kawasaki Araújo; Milena Simioni; Têmis Maria Félix; Liliane Todeschini de Souza; Marshall Ítalo Barros Fontes; Isabella Lopes Monlleó; Josiane Souza; Agnes Cristina Fett-Conte; Rodrigo Secolin; Iscia Lopes-Cendes; Cláudia Vianna Maurer-Morelli; Vera Lúcia Gil-da-Silva-Lopes
Journal:  Plast Surg Int       Date:  2012-11-27

8.  Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4.

Authors:  Yasuyuki Shiozaki; Takashi Kitajima; Tetsuro Mazaki; Aki Yoshida; Masato Tanaka; Akihiro Umezawa; Mariko Nakamura; Yasuhiro Yoshida; Yoshihiro Ito; Toshifumi Ozaki; Akihiro Matsukawa
Journal:  Int J Nanomedicine       Date:  2013-04-09
  8 in total

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