PURPOSE: Reduction of visual acuity in patients with central retinal vein occlusion (CRVO) is often caused by macular edema and ischemia. The major causative factor for macular changes may be a disturbance in the macular microcirculation. The authors studied the perifoveal microcirculation in patients with central retinal vein occlusion to quantify the extent of circulatory deficiency in the macular circulation. METHODS: Twenty-four patients (8 men, 16 women) with recently diagnosed CRVO were included in this study. The following data were quantified: mean capillary blood velocity (CBV), foveal avascular zone (FAZ), and mean perifoveal intercapillary area (PIA). RESULTS: In patients with CRVO, the mean flow velocity was significantly reduced compared with healthy subjects (1.63 +/- 0.220 mm/sec vs. 2.89 +/- 0.41 mm/sec, P < 0.01). The FAZ and the mean PIA characterizing capillary density were significantly enlarged in CRVO (5548 +/- 1151 microm2 vs. 3872 +/- 529 microm2; P < 0.01). CONCLUSIONS: The present study demonstrates that CRVO not only led to a decrease in capillary blood velocities, but also to an enlargement of perifoveal intercapillary areas in early stages of the disease.
PURPOSE: Reduction of visual acuity in patients with central retinal vein occlusion (CRVO) is often caused by macular edema and ischemia. The major causative factor for macular changes may be a disturbance in the macular microcirculation. The authors studied the perifoveal microcirculation in patients with central retinal vein occlusion to quantify the extent of circulatory deficiency in the macular circulation. METHODS: Twenty-four patients (8 men, 16 women) with recently diagnosed CRVO were included in this study. The following data were quantified: mean capillary blood velocity (CBV), foveal avascular zone (FAZ), and mean perifoveal intercapillary area (PIA). RESULTS: In patients with CRVO, the mean flow velocity was significantly reduced compared with healthy subjects (1.63 +/- 0.220 mm/sec vs. 2.89 +/- 0.41 mm/sec, P < 0.01). The FAZ and the mean PIA characterizing capillary density were significantly enlarged in CRVO (5548 +/- 1151 microm2 vs. 3872 +/- 529 microm2; P < 0.01). CONCLUSIONS: The present study demonstrates that CRVO not only led to a decrease in capillary blood velocities, but also to an enlargement of perifoveal intercapillary areas in early stages of the disease.
Authors: Alexander Pinhas; Moataz Razeen; Michael Dubow; Alexander Gan; Toco Y Chui; Nishit Shah; Mitul Mehta; Ronald C Gentile; Rishard Weitz; Joseph B Walsh; Yusufu N Sulai; Joseph Carroll; Alfredo Dubra; Richard B Rosen Journal: Invest Ophthalmol Vis Sci Date: 2014-11-20 Impact factor: 4.799
Authors: Amir H Kashani; Chieh-Li Chen; Jin K Gahm; Fang Zheng; Grace M Richter; Philip J Rosenfeld; Yonggang Shi; Ruikang K Wang Journal: Prog Retin Eye Res Date: 2017-07-29 Impact factor: 21.198
Authors: Diogo Cabral; Florence Coscas; Agnes Glacet-Bernard; Telmo Pereira; Carlos Geraldes; Francisco Cachado; Ana Papoila; Gabriel Coscas; Eric Souied Journal: Transl Vis Sci Technol Date: 2019-05-02 Impact factor: 3.283
Authors: Brian D Krawitz; Erika Phillips; Richard D Bavier; Shelley Mo; Joseph Carroll; Richard B Rosen; Toco Y P Chui Journal: Transl Vis Sci Technol Date: 2018-07-12 Impact factor: 3.283