Literature DB >> 9021759

Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemia-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil.

H Kabuto1, M Asanuma, S Nishibayashi, M Iida, N Ogawa.   

Abstract

We examined the effect of Oren-gedoku-to (TJ15), which is a traditional herbal Kampo prescription used as an anti-cerebral apoplexy agent on these changes. Chronic pre- and post-ischemia TJ15 oral administration almost completely abolished the ischemia-induced muscarinic receptor reduction and 5-hydroxyindoleacetic acid level increase. These results suggest that TJ15 prevents cholinergic synaptic dysfunction and serotonergic presynaptic hyperactivity induced by transient ischemia.

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Year:  1997        PMID： 9021759     DOI： 10.1023/a:1027369119224

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  22 in total

1.  Post-ischemic administration of bifemelane hydrochloride prohibits ischemia-induced depletion of the muscarinic M1-receptor and its mRNA in the gerbil hippocampus.

Authors:  N Ogawa; M Asanuma; K Mizukawa; H Hirata; H Chou; A Mori
Journal:  Brain Res       Date:  1992-09-18       Impact factor: 3.252

2.  Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia.

Authors:  G E Gibson; M Shimada; J P Blass
Journal:  J Neurochem       Date:  1978-10       Impact factor: 5.372

3.  Determination of acetylcholine and choline in perchlorate extracts of brain tissue using liquid chromatography-electrochemistry with an immobilized-enzyme reactor.

Authors:  K Fujimori; K Yamamoto
Journal:  J Chromatogr       Date:  1987-02-20

4.  The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia.

Authors:  N Ogawa; K Tanaka; Y Kondo; M Asanuma; K Mizukawa; A Mori
Journal:  Neurosci Lett       Date:  1993-04-02       Impact factor: 3.046

5.  Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.

Authors:  D C Mash; D D Flynn; L T Potter
Journal:  Science       Date:  1985-05-31       Impact factor: 47.728

6.  Anticholinesterase-induced amnesia and its temporal aspects.

Authors:  J A Deutsch; M D Hamburg; H Dahl
Journal:  Science       Date:  1966-01-14       Impact factor: 47.728

7.  Studies on muscarinic binding sites in human brain identified with [3H]pirenzepine.

Authors:  S C Lin; K C Olson; H Okazaki; E Richelson
Journal:  J Neurochem       Date:  1986-01       Impact factor: 5.372

8.  Comparison of the effects of bifemelane hydrochloride, idebenone and indeloxazine hydrochloride on ischemia-induced changes in brain monoamines and their metabolites in gerbils.

Authors:  K Haba; N Ogawa; M Asanuma; H Hirata; A Mori
Journal:  J Neural Transm Gen Sect       Date:  1992

9.  Effects of long-term recovery from transient cerebral ischemia in rat brain: tissue levels of acetylcholine, monoamines, and their metabolites.

Authors:  L Frölich; A Dirr; P Riederer; S Hoyer
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

10.  Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus.

Authors:  Y Kondo; N Ogawa; M Asanuma; S Nishibayashi; E Iwata; A Mori
Journal:  Neurosci Res       Date:  1995-03       Impact factor: 3.304
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  1 in total

1.  Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse.

Authors:  Y Kondo; F Kondo; M Asanuma; K Tanaka; N Ogawa
Journal:  Neurochem Res       Date:  2000-02       Impact factor: 3.996
  1 in total

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