Literature DB >> 9020589

Catalytic hydroxyl/amine dyads within serine proteases.

M Paetzel1, R E Dalbey.   

Abstract

The 'catalytic triad' mechanism, which involves a serine, histidine and aspartic acid, has become synonymous with serine proteases. However, recently, mechanistically novel serine proteases have been discovered. These proteases use hydroxyl/epsilon-amine or hydroxyl/alpha-amine 'catalytic dyads' as their reactive centers.

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Year:  1997        PMID： 9020589     DOI： 10.1016/s0968-0004(96)10065-7

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  31 in total

1.  Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism.

Authors:  M Paetzel; N C Strynadka
Journal:  Protein Sci       Date:  1999-11       Impact factor: 6.725

2.  Processing and maturation of the pilin of the type IV secretion system encoded within the gonococcal genetic island.

Authors:  Samta Jain; Jörg Kahnt; Chris van der Does
Journal:  J Biol Chem       Date:  2011-10-17       Impact factor: 5.157

3.  Identification of active sites in amidase: evolutionary relationship between amide bond- and peptide bond-cleaving enzymes.

Authors:  M Kobayashi; Y Fujiwara; M Goda; H Komeda; S Shimizu
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

4.  Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.

Authors:  Marius K Lemberg; Javier Menendez; Angelika Misik; Maite Garcia; Christopher M Koth; Matthew Freeman
Journal:  EMBO J       Date:  2004-12-23       Impact factor: 11.598

5.  Structural basis for intramembrane proteolysis by rhomboid serine proteases.

Authors:  Adam Ben-Shem; Deborah Fass; Eitan Bibi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-26       Impact factor: 11.205

6.  Crystal structure of a viral protease intramolecular acyl-enzyme complex: insights into cis-cleavage at the VP4/VP3 junction of Tellina birnavirus.

Authors:  Ivy Yeuk Wah Chung; Mark Paetzel
Journal:  J Biol Chem       Date:  2011-02-02       Impact factor: 5.157

7.  Cleavage of the NF-κB family protein p65/RelA by the chlamydial protease-like activity factor (CPAF) impairs proinflammatory signaling in cells infected with Chlamydiae.

Authors:  Jan Christian; Juliane Vier; Stefan A Paschen; Georg Häcker
Journal:  J Biol Chem       Date:  2010-11-01       Impact factor: 5.157

8.  SipA is required for pilus formation in Streptococcus pyogenes serotype M3.

Authors:  Dorothea Zähner; June R Scott
Journal:  J Bacteriol       Date:  2007-11-09       Impact factor: 3.490

9.  Expression, purification and crystallization of a birnavirus-encoded protease, VP4, from blotched snakehead virus (BSNV).

Authors:  Jaeyong Lee; Anat R Feldman; Bernard Delmas; Mark Paetzel
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-03-10

10.  Carboxyl-terminal protease regulates Brucella suis morphology in culture and persistence in macrophages and mice.

Authors:  Aloka B Bandara; Nammalwar Sriranganathan; Gerhardt G Schurig; Stephen M Boyle
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490
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