| Literature DB >> 9018094 |
S Ohwada1, I Kobayashi, M Maemura, Y Satoh, T Ogawa, Y Iino, Y Morishita.
Abstract
We studied the antiproliferative effect of recombinant human interferon-alpha/beta/gamma (rHuIFN-alpha/beta/gamma) and CPT-11 against human colon cancer xenografts in nude mice. CPT-11 (25 mg/kg) alone exhibited significant antiproliferative effects. Although rHuIFN-alpha/beta/gamma alone did not show antiproliferative activity, it markedly enhanced the antiproliferative activity of CPT-11. rHuIFN-alpha/beta/gamma significantly increased in the population of cells in the S-phase. rHuIFN-alpha/beta/gamma progressed cell cycle in the S-phase under the existence of CPT-11, which exhibited no effect on cell cycle progression. Because CPT-11 is known to exhibit antiproliferative effect on S-phase cells, IFNs, especially rHuIFN-alpha and beta, can enhance the antiproliferative effect of CPT-11 mediated by cell accumulation in the S-phase.Entities:
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Year: 1996 PMID： 9018094 DOI： 10.1016/s0304-3835(96)04477-1
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679