Literature DB >> 901785

Membranes undergoing phase transitions are preferentially hydrolyzed by beta-bungarotoxin.

P N Strong, R B Kelly.   

Abstract

beta-Bungarotoxin preferentially hydrolyzes choline phospholipids (dilauroyl, dimyristoyl, dipalmitoyl) at their respective gel to liquid crystalline phase transition temperatures. Cholesterol markedly reduces the rate of phospholipid hydrolysis; at 0.33 mol percent cholesterol:phospholipid, the toxin's phospholipase activity is completely inhibited.

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Year:  1977        PMID: 901785     DOI: 10.1016/0005-2736(77)90187-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  1 in total

1.  Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle.

Authors:  B J Hawgood; I C Smith; P N Strong
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

  1 in total

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