| Literature DB >> 9017471 |
D Compas1, D J Touw, P N de Goede.
Abstract
An assay for the determination of itraconazole and its active metabolite hydroxyitraconazole in serum has been developed, using ketoconazole as internal standard. The procedure involved a one-step liquid-liquid extraction of the drug, its metabolite and the internal standard, followed by their separation by reversed-phase HPLC. In this paper the validation of this method is described.Entities:
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Year: 1996 PMID： 9017471 DOI： 10.1016/s0378-4347(96)00245-9
Source DB: PubMed Journal: J Chromatogr B Biomed Appl ISSN： 1572-6495