OBJECTIVES: To determine cerebral atrophy parameters on MRI images of epileptic patients. MATERIAL AND METHODS: Examination of the brain was performed in a 0.5 Tesla magnet in 32 women with epilepsy and 36 female healthy controls. Fifteen patients were classified to have generalised epilepsy and 17 had partial seizure onset. Epileptic patients with structural brain changes were excluded. At midsagittal level the area of corpus callosum, cerebrum and cerebellum were selected as atrophy parameters. At transverse level the ventricle-brain ratio (VBR) as a measure of overall cerebral atrophy, bifrontal ratio (BFR) reflecting atrophy in the area of the frontal horns, bicaudate ratio (BCR) and bioccipital ratio (BOR) were calculated to evaluate atrophy in the region of nucleus caudatus as well as in the occipital area. RESULTS: The mean values of VBR were significantly larger in the two epileptic groups than in controls, p = 0.0003. No significant difference in mean VBR were found between focal and generalised seizure onset epilepsy. Also significant decreased cerebellar area on midsagittal section was detected in epileptic patients with partial onset epilepsy compared with controls, p = 0.037. Atrophy was not associated with type and duration of epilepsy, but VBR and age were positively associated in patients with generalised onset seizures. CONCLUSION: These findings suggest general brain atrophy to be present in epileptic patients including those with partial epilepsy. Whether atrophy in epileptic patients occurs as a consequence of disease-related factors like hypoxia or treatment with antiepileptic drugs has to be investigated in a prospectively designed study.
OBJECTIVES: To determine cerebral atrophy parameters on MRI images of epilepticpatients. MATERIAL AND METHODS: Examination of the brain was performed in a 0.5 Tesla magnet in 32 women with epilepsy and 36 female healthy controls. Fifteen patients were classified to have generalised epilepsy and 17 had partial seizure onset. Epilepticpatients with structural brain changes were excluded. At midsagittal level the area of corpus callosum, cerebrum and cerebellum were selected as atrophy parameters. At transverse level the ventricle-brain ratio (VBR) as a measure of overall cerebral atrophy, bifrontal ratio (BFR) reflecting atrophy in the area of the frontal horns, bicaudate ratio (BCR) and bioccipital ratio (BOR) were calculated to evaluate atrophy in the region of nucleus caudatus as well as in the occipital area. RESULTS: The mean values of VBR were significantly larger in the two epileptic groups than in controls, p = 0.0003. No significant difference in mean VBR were found between focal and generalised seizure onset epilepsy. Also significant decreased cerebellar area on midsagittal section was detected in epilepticpatients with partial onset epilepsy compared with controls, p = 0.037. Atrophy was not associated with type and duration of epilepsy, but VBR and age were positively associated in patients with generalised onset seizures. CONCLUSION: These findings suggest general brain atrophy to be present in epilepticpatients including those with partial epilepsy. Whether atrophy in epilepticpatients occurs as a consequence of disease-related factors like hypoxia or treatment with antiepileptic drugs has to be investigated in a prospectively designed study.
Authors: Tracy Butler; Laszlo Zaborszky; Xiuyuan Wang; Carrie R McDonald; Karen Blackmon; Brian T Quinn; Jonathan DuBois; Chad Carlson; William B Barr; Jacqueline French; Ruben Kuzniecky; Eric Halgren; Orrin Devinsky; Thomas Thesen Journal: Neurology Date: 2013-01-09 Impact factor: 9.910
Authors: Manar Ibdali; Marios Hadjivassiliou; Richard A Grünewald; Priya D Shanmugarajah Journal: Int J Environ Res Public Health Date: 2021-01-08 Impact factor: 3.390
Authors: Magdalena Maria Woźniak; Monika Zbroja; Małgorzata Matuszek; Olga Pustelniak; Weronika Cyranka; Katarzyna Drelich; Ewa Kopyto; Andrzej Materniak; Tomasz Słomka; Maciej Cebula; Agnieszka Brodzisz Journal: J Clin Med Date: 2022-08-09 Impact factor: 4.964