Literature DB >> 9015379

Free cytosolic calcium levels modify intracellular pH in rat pancreatic acini.

A González1, P J Camello, J A Pariente, G M Salido.   

Abstract

We have used BCECF- or Fura-2-loaded rat pancreatic acinar cells to investigate the relationship between Ca2+ mobilization and intracellular pH (pHi). Ca2+-mobilizing agonists CCK-8 and ACh induced a transient acidification totally dependent on release of Ca2+ from internal stores. Employment of different physiological tools including ionomycin and thapsigargin to increase the cytosolic Ca2+ concentration and capacitative calcium influx also induced cellular acidification. Application of 1mM LaCl3 reduced the CCK-8-evoked acidification. These data indicate that the mobilization of intracellular Ca2+ stores by CCK-8 decreases cellular pH by Ca2+/H+ exchanger.

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Year:  1997        PMID： 9015379     DOI： 10.1006/bbrc.1996.6026

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Resveratrol mobilizes Ca2+ from intracellular stores and induces c-Jun N-terminal kinase activation in tumoral AR42J cells.

Authors:  Lourdes Garcia-Sanchez; Patricia Santofimia-Castaño; Alvaro Miro-Moran; Jose A Tapia; Gines M Salido; Antonio Gonzalez
Journal:  Mol Cell Biochem       Date:  2011-10-20       Impact factor: 3.396

2.  Effect of dephostatin on intracellular free calcium concentration and amylase secretion in isolated rat pancreatic acinar cells.

Authors:  A I Lajas; M J Pozo; P J Camello; G M Salido; J Singh; J A Pariente
Journal:  Mol Cell Biochem       Date:  2000-02       Impact factor: 3.396

3.  Ethanol consumption as inductor of pancreatitis.

Authors:  José A Tapia; Ginés M Salido; Antonio González
Journal:  World J Gastrointest Pharmacol Ther       Date:  2010-02-06

4.  Sequential activation of different Ca2+ entry pathways upon cholinergic stimulation in mouse pancreatic acinar cells.

Authors:  C Camello; J A Pariente; G M Salido; P J Camello
Journal:  J Physiol       Date:  1999-04-15       Impact factor: 5.182

5.  Cinnamtannin B-1, a natural antioxidant that reduces the effects of H(2)O(2) on CCK-8-evoked responses in mouse pancreatic acinar cells.

Authors:  Antonio Gonzalez; Patricia Santofimia-Castaño; Ramon Rivera-Barreno; Gines M Salido
Journal:  J Physiol Biochem       Date:  2011-11-26       Impact factor: 4.158

6.  Melatonin modulates Ca2+ mobilization and amylase release in response to cholecystokinin octapeptide in mouse pancreatic acinar cells.

Authors:  Patricia Santofimia-Castaño; Deborah Clea Ruy; Ginés M Salido; Antonio González
Journal:  J Physiol Biochem       Date:  2013-08-02       Impact factor: 4.158

7.  Effect of Chaiqin Chengqi Decoction on cholecystokinin receptor 1-mediated signal transduction of pancreatic acinar cells in acute necrotizing pancreatitis rats.

Authors:  Jia Guo; Tao Jin; Zi-Qi Lin; Xiao-Xiang Wang; Xiao-Nan Yang; Qing Xia; Ping Xue
Journal:  Chin J Integr Med       Date:  2014-05-10       Impact factor: 1.978

8.  Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells.

Authors:  Angel Del Castillo-Vaquero; Ginés M Salido; Antonio González
Journal:  Int J Exp Pathol       Date:  2009-12-04       Impact factor: 1.925

9.  Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells.

Authors:  Marcela Fernández-Sánchez; Angel del Castillo-Vaquero; Ginés M Salido; Antonio González
Journal:  BMC Cell Biol       Date:  2009-10-30       Impact factor: 4.241

10.  Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells.

Authors:  Patricia Santofimia-Castaño; Deborah Clea Ruy; Miguel Fernandez-Bermejo; Gines M Salido; Antonio Gonzalez
Journal:  Mol Cell Biochem       Date:  2014-08-02       Impact factor: 3.396
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