Literature DB >> 9015317

Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system.

M S Duxon1, T P Flanigan, A C Reavley, G S Baxter, T P Blackburn, K C Fone.   

Abstract

The 5-hydroxytryptamine-2B receptor is the most recent addition to the 5-hydroxytryptamine-2 family of G-protein-coupled receptors. In the rat stomach fundus, 5-hydroxytryptamine-2B receptor activation causes contraction; however, its distribution and function in the rat CNS are unclear. By performing immunohistochemistry with an antiserum raised against the N-terminus of the 5-hydroxytryptamine-2B receptor protein, this study identifies receptor expression in longitudinal and circular smooth muscle in the rat stomach fundus and in neurons in discrete nuclei in the cerebellum, lateral septum, dorsal hypothalamus and medial amygdala. The potential function of this receptor in the CNS is discussed.

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Year:  1997        PMID： 9015317     DOI： 10.1016/s0306-4522(96)00480-0

Source DB:  PubMed          Journal:  Neuroscience        ISSN： 0306-4522            Impact factor:   3.590


  35 in total

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