PURPOSE: To evaluate the effectiveness of positron emission tomography (PET) with carbon-11 choline in brain tumor imaging. MATERIALS AND METHODS: A rat glioma cell line (C6) was incubated with C-14 choline; the time course of uptake and metabolism was determined in vitro. C-11 choline was injected intravenously in tumor-bearing rats; the time course of distribution in organs was determined. C-11 choline also was injected intravenously in 20 patients (aged 6-86 years) with brain tumors and two volunteers (aged 38 and 58 years); distribution of the tracer in the brain was determined. Regional cerebral blood flow was measured by using oxygen-15 water on the same day. RESULTS: C-14 choline was metabolized to phosphoryl choline in glioma cells. The uptake of C-11 choline by glioblastoma cells was three to four times higher than that in the rat brain. All brain tumors took up more C-11 choline than did normal brain; thus, brain tumors that were not treated, as well as those that were treated with surgery or radiation therapy, were depicted. The tumor-normal brain uptake ratio of C-11 choline in brain tumor did not correlate with the O-15 water regional blood flow in the corresponding area. CONCLUSION: C-11 choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery.
PURPOSE: To evaluate the effectiveness of positron emission tomography (PET) with carbon-11 choline in brain tumor imaging. MATERIALS AND METHODS: A ratglioma cell line (C6) was incubated with C-14choline; the time course of uptake and metabolism was determined in vitro. C-11choline was injected intravenously in tumor-bearing rats; the time course of distribution in organs was determined. C-11choline also was injected intravenously in 20 patients (aged 6-86 years) with brain tumors and two volunteers (aged 38 and 58 years); distribution of the tracer in the brain was determined. Regional cerebral blood flow was measured by using oxygen-15 water on the same day. RESULTS:C-14choline was metabolized to phosphoryl choline in glioma cells. The uptake of C-11choline by glioblastoma cells was three to four times higher than that in the rat brain. All brain tumors took up more C-11choline than did normal brain; thus, brain tumors that were not treated, as well as those that were treated with surgery or radiation therapy, were depicted. The tumor-normal brain uptake ratio of C-11choline in brain tumor did not correlate with the O-15 water regional blood flow in the corresponding area. CONCLUSION:C-11choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery.
Authors: M Utriainen; M Komu; V Vuorinen; P Lehikoinen; P Sonninen; T Kurki; T Utriainen; A Roivainen; H Kalimo; H Minn Journal: J Neurooncol Date: 2003-05 Impact factor: 4.130