OBJECTIVE: To determine the prevalence of human papillomavirus (HPV) DNA types 6, 11 and 16 in histological sections of human bladder cancer. MATERIALS AND METHODS: Fifty-five formalin-fixed, paraffin-embedded bladder tumour specimens were analysed for the presence of HPV infection using Southern blotting DNA hybridization and radiolabelled probes for HPV DNA types 6/11 and 16. RESULTS: Despite the detection of HPV DNA type 6, 11 and 16 in positive control samples and the successful detection of HPV DNA in anogenital cancer using the same technique, no HPV DNA was found in any of the bladder tumour specimens examined. CONCLUSIONS: Using a technique with proven efficacy in the detection of HPV DNA from histological specimens, no HPV DNA was present in any of the bladder tumours examined. This finding is in agreement with most recently published studies suggesting that HPV has no significant role in the development of human bladder cancer.
OBJECTIVE: To determine the prevalence of human papillomavirus (HPV) DNA types 6, 11 and 16 in histological sections of humanbladder cancer. MATERIALS AND METHODS: Fifty-five formalin-fixed, paraffin-embedded bladder tumour specimens were analysed for the presence of HPV infection using Southern blotting DNA hybridization and radiolabelled probes for HPV DNA types 6/11 and 16. RESULTS: Despite the detection of HPV DNA type 6, 11 and 16 in positive control samples and the successful detection of HPV DNA in anogenital cancer using the same technique, no HPV DNA was found in any of the bladder tumour specimens examined. CONCLUSIONS: Using a technique with proven efficacy in the detection of HPV DNA from histological specimens, no HPV DNA was present in any of the bladder tumours examined. This finding is in agreement with most recently published studies suggesting that HPV has no significant role in the development of humanbladder cancer.
Authors: Ioannis N Mammas; George Sourvinos; Apostolos Zaravinos; Demetrios A Spandidos Journal: Pathol Oncol Res Date: 2010-07-18 Impact factor: 3.201
Authors: Georgios I Panagiotakis; Danae Papadogianni; Maria N Chatziioannou; Ismini Lasithiotaki; Dimitrios Delakas; Demetrios A Spandidos Journal: Tumour Biol Date: 2012-09-13
Authors: Socorro María Rodríguez-Pinilla; José Luis Rodríguez-Peralto; María Teresa Férnandez-Figueras Journal: Virchows Arch Date: 2003-05-01 Impact factor: 4.064