| Literature DB >> 9014346 |
H M Garraffo1, P Jain, T F Spande, J W Daly.
Abstract
The structure of alkaloid 223A (1), the first member of a new class of amphibian alkaloids, purified by HPLC from a skin extract of a Panamanian population of the frog Dendrobates pumilio Schmidt (Dendrobatidae) has been established as (5R,6S,8R,9S)- or (5S,6R,8S,9R)-6,8-diethyl-5-propylindolizidine, based on GC-MS, GC-FTIR, and 1H-NMR spectral studies. Three higher homologs of 223A, namely alkaloids 237L (2), 251M (3), and 267J (4), have been detected in other extracts, and tentative structures are proposed.Entities:
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Year: 1997 PMID： 9014346 DOI： 10.1021/np960522l
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050