Literature DB >> 9013411

CGP 39653 binding in the chick CNS after NMDA receptor antagonist treatment.

B H White1, M W Vogel.   

Abstract

To analyze the affect of blocking neuronal activity on NMDA receptor levels during development, we have injected chick embryos with the competitive NMDA receptor antagonist NPC 12626 from E17 to E19. Brains from drug-treated (n = 7) and control (n = 6) embryos (E20) were processed for receptor autoradiography using the NMDA competitive antagonist [3H]CGP 39653. NPC 12626 treatment caused a significant 24 to 46% increase in [3H]CGP 39653 binding in both the forebrain and cerebellar cortex. The results support the hypothesis that NMDA receptor levels are regulated by activity-dependent mechanisms.

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Year:  1996        PMID： 9013411     DOI： 10.1007/BF01271185

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  13 in total

Review 1.  Physiological and pathophysiological roles of excitatory amino acids during central nervous system development.

Authors:  J W McDonald; M V Johnston
Journal:  Brain Res Brain Res Rev       Date:  1990 Jan-Apr

2.  [3H]MK-801 binding in immature and mature chicken forebrain.

Authors:  J M Kavanagh; P R Dodd; J A Rostas
Journal:  Neurosci Lett       Date:  1991-12-16       Impact factor: 3.046

3.  Cerebellar excitatory amino acid binding sites in normal, granuloprival, and Purkinje cell-deficient mice.

Authors:  R L Makowiec; J J Cha; J B Penney; A B Young
Journal:  Neuroscience       Date:  1991       Impact factor: 3.590

4.  [3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain.

Authors:  M A Sills; G Fagg; M Pozza; C Angst; D E Brundish; S D Hurt; E J Wilusz; M Williams
Journal:  Eur J Pharmacol       Date:  1991-01-03       Impact factor: 4.432

5.  Down-regulation of NMDA receptor activity by NMDA.

Authors:  Y Oster; M Schramm
Journal:  Neurosci Lett       Date:  1993-11-26       Impact factor: 3.046

6.  Formation and differentiation of the external granular layer of the chick cerebellum.

Authors:  J Hanaway
Journal:  J Comp Neurol       Date:  1967-09       Impact factor: 3.215

7.  MK-801 pretreatment enhances N-methyl-D-aspartate-mediated brain injury and increases brain N-methyl-D-aspartate recognition site binding in rats.

Authors:  J W McDonald; F S Silverstein; M V Johnston
Journal:  Neuroscience       Date:  1990       Impact factor: 3.590

8.  Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development.

Authors:  S Rabacchi; Y Bailly; N Delhaye-Bouchaud; J Mariani
Journal:  Science       Date:  1992-06-26       Impact factor: 47.728

9.  Plasticity of NMDA receptor expression during mouse cerebellar granule cell development.

Authors:  M Didier; J M Mienville; P Soubrié; J Bockaert; S Berman; S Bursztajn; J P Pin
Journal:  Eur J Neurosci       Date:  1994-10-01       Impact factor: 3.386

10.  Chronic NMDA receptor blockade or muscimol inhibition of cerebellar cortical neuronal activity alters the development of spinocerebellar afferent topography.

Authors:  D L Tolbert; T Pittman; J M Alisky; B R Clark
Journal:  Brain Res Dev Brain Res       Date:  1994-07-15
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