Literature DB >> 9013206

Scavenging of hypochlorous acid by carvedilol and ebselen in vitro.

O I Aruoma1.   

Abstract

1. The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3. Ebselen was resistant to HOCl when its glutathione-peroxidase mimetic property was compared with that of glutathione peroxidase.

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Year:  1997        PMID： 9013206     DOI： 10.1016/s0306-3623(96)00232-7

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  3 in total

1.  Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers.

Authors:  Stefanie A Fahlbusch; Dimitrios Tsikas; Christina Mehls; Frank-Mathias Gutzki; Rainer H Böger; Jürgen C Frölich; Dirk O Stichtenoth
Journal:  Eur J Clin Pharmacol       Date:  2004-03-05       Impact factor: 2.953

2.  The inhibition in tumor necrosis factor-alpha-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-kappaB and reactive oxygen species.

Authors:  Pen-Yuan Lin; Hsi-Che Shen; Chien-Jen Chen; Shu-En Wu; Hsien-Li Kao; Jen-Hung Huang; Danny Ling Wang; Shih-Chung Chen
Journal:  J Thromb Thrombolysis       Date:  2009-03-31       Impact factor: 2.300

Review 3.  Toxicology and pharmacology of synthetic organoselenium compounds: an update.

Authors:  Cristina W Nogueira; Nilda V Barbosa; João B T Rocha
Journal:  Arch Toxicol       Date:  2021-04-01       Impact factor: 6.168
  3 in total

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