| Literature DB >> 90129 |
A B Keith, R Arnon, D Teitelbaum, E A Caspary, H M Wisniewski.
Abstract
Cop 1, a synthetic polypeptide, was evaluated for its effect on a chronic relapsing form of experimental allergic encephalomyelitis (EAE). Pretreatment of juvenile Strain 13 guinea pigs with Cop 1 in incomplete Freund's adjuvant (IFA) which were subsequently challenged with guinea pig spinal cord in complete Freund's adjuvant (CFA) had a marked effect in delaying or preventing the appearance of clinical signs of EAE. Administration of Cop 1 on appearance of clinical signs of EAE prevented progression of the first episode of the disease. Although relapses were not always prevented, they were modified on their duration and intensity both clinically and histologically.Entities:
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Year: 1979 PMID： 90129 DOI： 10.1016/0022-510x(79)90058-3
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181