Literature DB >> 9010305

Transforming growth factor beta production during rat cytomegalovirus infection.

B L Haagmans1, K J Teerds, A J van den Eijnden-van Raaij, M C Horzinek, V E Schijns.   

Abstract

We analysed the production of transforming growth factor beta (TGF-beta) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-beta1. TGF-beta production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-beta antibodies. In addition, TGF-beta production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-beta was produced upon RCMV infection in vitro. The induction of TGF-beta production may contribute to immunosuppression during CMV infection.

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Year:  1997        PMID： 9010305     DOI： 10.1099/0022-1317-78-1-205

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  6 in total

1.  Transforming growth factor beta-induced failure of resistance to infection with blood-stage Plasmodium chabaudi in mice.

Authors:  N Tsutsui; T Kamiyama
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

2.  Profile of transforming growth factor-beta 1 in patients with dengue haemorrhagic fever.

Authors:  R Agarwal; E A Elbishbishi; U C Chaturvedi; R Nagar; A S Mustafa
Journal:  Int J Exp Pathol       Date:  1999-06       Impact factor: 1.925

3.  Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.

Authors:  Takako Tabata; Hisaaki Kawakatsu; Ekaterina Maidji; Takao Sakai; Keiko Sakai; June Fang-Hoover; Motohiko Aiba; Dean Sheppard; Lenore Pereira
Journal:  Am J Pathol       Date:  2008-03-18       Impact factor: 4.307

4.  Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter.

Authors:  Jing Qing; Cheng Liu; Lisa Choy; Rui-Yun Wu; Joseph S Pagano; Rik Derynck
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

5.  TGF-beta1 suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler's virus.

Authors:  Ikuo Tsunoda; Jane E Libbey; Robert S Fujinami
Journal:  J Neuroimmunol       Date:  2007-09-04       Impact factor: 3.478

Review 6.  Cytomegaloviruses and Macrophages-Friends and Foes From Early on?

Authors:  Sebastian Baasch; Zsolt Ruzsics; Philipp Henneke
Journal:  Front Immunol       Date:  2020-05-12       Impact factor: 7.561
  6 in total

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