Literature DB >> 9009342

Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages.

C Peters1, Y D Stierhof, T Ilg.   

Abstract

The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.

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Year:  1997        PMID： 9009342      PMCID： PMC176125          DOI： 10.1128/iai.65.2.783-786.1997

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Rotary shadowing of extended molecules dried from glycerol.

Authors:  J M Tyler; D Branton
Journal:  J Ultrastruct Res       Date:  1980-05

2.  Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH.

Authors:  J C Antoine; E Prina; C Jouanne; P Bongrand
Journal:  Infect Immun       Date:  1990-03       Impact factor: 3.441

3.  Purification and structural characterization of a filamentous, mucin-like proteophosphoglycan secreted by Leishmania parasites.

Authors:  T Ilg; Y D Stierhof; D Craik; R Simpson; E Handman; A Bacic
Journal:  J Biol Chem       Date:  1996-08-30       Impact factor: 5.157

4.  Destruction of Leishmania mexicana amazonensis amastigotes within macrophages by lysosomotropic amino acid esters.

Authors:  M Rabinovitch; V Zilberfarb; C Ramazeilles
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307

5.  Lysosomal depletion in macrophages from spleen and foot lesions of Leishmania-infected hamster.

Authors:  C L Barbiéri; A I Doine; E Freymuller
Journal:  Exp Parasitol       Date:  1990-08       Impact factor: 2.011

6.  The regulation of pinocytosis in mouse macrophages. II. Factors inducing vesicle formation.

Authors:  Z A Cohn; E Parks
Journal:  J Exp Med       Date:  1967-02-01       Impact factor: 14.307

7.  Phorbol myristate acetate stimulates phagosome-lysosome fusion in mouse macrophages.

Authors:  M C Kielian; Z A Cohn
Journal:  J Exp Med       Date:  1981-07-01       Impact factor: 14.307

8.  Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes.

Authors:  M C Kielian; R M Steinman; Z A Cohn
Journal:  J Cell Biol       Date:  1982-06       Impact factor: 10.539

9.  Receptor-mediated entry of beta-glucuronidase into the parasitophorous vacuoles of macrophages infected with Leishmania mexicana amazonensis.

Authors:  V L Shepherd; P D Stahl; P Bernd; M Rabinovitch
Journal:  J Exp Med       Date:  1983-05-01       Impact factor: 14.307

10.  Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity.

Authors:  M C Kielian; Z A Cohn
Journal:  J Cell Biol       Date:  1982-06       Impact factor: 10.539
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  8 in total

1.  Proteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.

Authors:  U Göpfert; N Goehring; C Klein; T Ilg
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

2.  Proteophosphoglycans of Leishmania mexicana. Identification, purification, structural and ultrastructural characterization of the secreted promastigote proteophosphoglycan pPPG2, a stage-specific glycoisoform of amastigote aPPG.

Authors:  C Klein; U Göpfert; N Goehring; Y D Stierhof; T Ilg
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

3.  Proteophosphoglycan, a major secreted product of intracellular Leishmania mexicana amastigotes, is a poor B-cell antigen and does not elicit a specific conventional CD4+ T-cell response.

Authors:  T Aebischer; D Harbecke; T Ilg
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

Review 4.  Host Organelle Hijackers: a similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis: co-infection model as a tool to investigate pathogenesis.

Authors:  Julia D Romano; Isabelle Coppens
Journal:  Pathog Dis       Date:  2013-07-22       Impact factor: 3.166

5.  Glycoinositolphospholipids from Trypanosoma cruzi interfere with macrophages and dendritic cell responses.

Authors:  Claudia Brodskyn; Julie Patricio; Rubem Oliveira; Lucas Lobo; Andrea Arnholdt; Lucia Mendonça-Previato; Aldina Barral; Manoel Barral-Netto
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441

6.  Proteinases as virulence factors in Leishmania spp. infection in mammals.

Authors:  Mariana Silva-Almeida; Bernardo Acácio Santini Pereira; Michelle Lopes Ribeiro-Guimarães; Carlos Roberto Alves
Journal:  Parasit Vectors       Date:  2012-08-07       Impact factor: 3.876

7.  Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages.

Authors:  Fernando Real; Renato A Mortara; Michel Rabinovitch
Journal:  PLoS Negl Trop Dis       Date:  2010-12-07

8.  The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging.

Authors:  Fernando Real; Renato A Mortara
Journal:  PLoS Negl Trop Dis       Date:  2012-02-14
  8 in total

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