Literature DB >> 9009225

Purification of ADAM 10 from bovine spleen as a TNFalpha convertase.

C A Lunn1, X Fan, B Dalie, K Miller, P J Zavodny, S K Narula, D Lundell.   

Abstract

We have purified a protease with characteristics of TNFalpha convertase from bovine spleen membranes. Peptide sequencing of the purified protein identified it as ADAM 10 (Genbank accession no. Z21961). This metalloprotease cleaves a recombinant proTNFalpha substrate to mature TNFalpha, and can cleave a synthetic peptide substrate to yield the mature TNFalpha amino terminus in vitro. The enzyme is sensitive to a hydroxamate inhibitor of MMPs, but insensitive to phosphoramidon. In addition, cloned ADAM 10 mediates proTNFalpha processing in a processing-incompetent cell line.

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Year:  1997        PMID： 9009225     DOI： 10.1016/s0014-5793(96)01410-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

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4.  Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.

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5.  LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.

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7.  The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer.

Authors:  Sercan Ergün; Mustafa Ulasli; Yusuf Ziya Igci; Mehri Igci; Sevil Kırkbes; Ersin Borazan; Ahmet Balik; Önder Yumrutaş; Celalettin Camci; Ecir Ali Cakmak; Ahmet Arslan; Serdar Oztuzcu
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8.  Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel.

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9.  Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.

Authors:  S Lammich; E Kojro; R Postina; S Gilbert; R Pfeiffer; M Jasionowski; C Haass; F Fahrenholz
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10.  MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.

Authors:  Amantha Thathiah; Daniel D Carson
Journal:  Biochem J       Date:  2004-08-15       Impact factor: 3.857
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